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dc.contributor.authorYiğiner, Ömer
dc.contributor.authorDoğan, Mehmet
dc.contributor.authorGün, İsmet
dc.contributor.authorKutlu, Hüseyin Tayfun
dc.contributor.authorDeğirmencioğlu, Gökhan
dc.contributor.authorGüliyev, İlkin
dc.contributor.authorTokatlı, Alptuğ
dc.contributor.authorKılıçaslan, Fethi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2018en_US
dc.identifier.citationYiğiner, Ö., Doğan, M., Gün, İ., Kutlu, H. T., Değirmencioğlu, G., Güliyev, İ. ... Kılıçaslan, F. (2018). The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters. Kardiologia Polska, 76(6), 974-979. https://dx.doi.org/10.5603/KP.a2018.0037en_US
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.urihttps://dx.doi.org/10.5603/KP.a2018.0037
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3353
dc.descriptionWOS: 000435195800008en_US
dc.descriptionPubMed ID: 29399762en_US
dc.description.abstractBackground: The frequency of arrhythmic death developing without a structural cardiac disease is higher in women. Also, female sex is an independent risk factor regarding development of torsades de pointes. Several studies have been conducted on the physiological and therapeutic effects of sex hormones on the cardiac conduction system. Aim: In this study we aim to examine the effect of hormonal changes, especially supraphysiological E2 level changes occurring during in vitro fertilisation treatment, on ventricular repolarisation parameters. Methods: The study included female patients aged between 23 and 39 years, who were administered controlled ovarian hyperstimulation treatment. Patients' electrocardiograms and blood samples were obtained and analysed before and after the ovarian hyperstimulation treatment. Results: Mean QTc intervals before ovarian hyperstimulation were 411.9 +/- 23.7 ms. Measurements during oestradiol peak were calculated as 420.7 +/- 23.3 ms, and the QTc interval increase was significant (p = 0.007). Corrected QT dispersion averages were not significant before or after hyperstimulation (53 +/- 17 ms vs. 54.5 +/- 18.2 ms, respectively, p > 0.05). Tp-e, J-T peak, and PR dispersion changes were not significant after the ovarian hyperstimulation therapy. Conclusions: Supraphysiological oestradiol levels that occur during controlled ovarian hyperstimulation cause prolongation of QTc intervals, but not to a pathological level. Although this prolongation is not significant in healthy individuals, it might increase ventricular arrhythmia risk in patients with congenital long QT syndrome and in patients taking medication that prolongs QT.en_US
dc.language.isoengen_US
dc.publisherVia Medicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOestrogenen_US
dc.subjectQT Intervalen_US
dc.subjectQT Dispersionen_US
dc.subjectVentricular Repolarisationen_US
dc.subjectOvulation Inductionen_US
dc.subjectIn Vitro Fertilisationen_US
dc.titleThe effects of supraphysiological oestrogen levels on ventricular repolarisation parametersen_US
dc.typearticleen_US
dc.relation.journalKardiologia Polskaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.identifier.volume76en_US
dc.identifier.issue6en_US
dc.identifier.startpage974en_US
dc.identifier.endpage979en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5603/KP.a2018.0037en_US


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