Show simple item record

dc.contributor.authorNaki, Mehmet Murat
dc.contributor.authorOran, Gülbin
dc.contributor.authorTetikkurt, Seza Ümit
dc.contributor.authorSönmez, Cavide Fatma
dc.contributor.authorTürkmen, İlknur
dc.contributor.authorKöse, Faruk
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:33Z
dc.date.issued2017en_US
dc.identifier.citationNaki, M. N., Oran, G., Tetikkurt, S. Ü., Sönmez, C. F., Türkmen, İ. ve Köse, F. (2017). Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma. Journal of the Turkish-German Gynecological Association, 18(3), 139-142. https://dx.doi.org/10.4274/jtgga.2017.0016en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.2017.0016
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3334
dc.descriptionWOS: 000423954800008en_US
dc.descriptionPubMed ID: 28890428en_US
dc.description.abstractObjective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0% and 38.6% of patients, respectively. Depth of myometrial invasion was <50% in 72.0% of patients, and LVSI was absent in 77.1%. MELF pattern was confirmed in 35 (42.2%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III; 85.7% vs. 14.3%, p<0.001), deep (>= 50%) myometrial invasion (78.3% vs. 21.7%, p<0.001), and presence of LVSI (94.7% vs. 5.3%, p<0.001) as compared with absence of MELF pattern. Conclusion: In conclusion, our findings revealed a high rate of MELF pattern among patients with EEA alongside the association of MELF pattern with poor prognostic factors such as high grade tumor, deep myometrial invasion, and LVSI.en_US
dc.language.isoengen_US
dc.publisherGalenos Yayıncılıken_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrioid Endometrial Adenocarcinomaen_US
dc.subjectMicrocysticen_US
dc.subjectElongateden_US
dc.subjectFragmented Patternen_US
dc.subjectTumor Gradeen_US
dc.subjectMyometrial Invasionen_US
dc.subjectLymphovascular Space Invasionen_US
dc.titleMicrocystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinomaen_US
dc.typearticleen_US
dc.relation.journalJournal of the Turkish-German Gynecological Associationen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-6708-7791en_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.startpage139en_US
dc.identifier.endpage142en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4274/jtgga.2017.0016en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record