dc.contributor.author | Kurgan, Şivge | |
dc.contributor.author | Önder, Canan | |
dc.contributor.author | Balcı, Nur | |
dc.contributor.author | Fentoğlu, Özlem | |
dc.contributor.author | Eser, Filiz | |
dc.contributor.author | Balseven, Müge | |
dc.contributor.author | Serdar, Muhittin Abdülkadir | |
dc.contributor.author | Tatakis, Dimitris N. | |
dc.contributor.author | Günhan, Meral | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:27Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:27Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Kurgan, Ş., Önder, C., Balcı, N., Fentoğlu, Ö.,
Eser, F., Balseven, M. ... Günhan, M. (2017). Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy. Journal of Periodontal Research, 52(3), 574-581. https://dx.doi.org/10.1111/jre.12425 | en_US |
dc.identifier.issn | 0022-3484 | |
dc.identifier.issn | 1600-0765 | |
dc.identifier.uri | https://dx.doi.org/10.1111/jre.12425 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3280 | |
dc.description | WOS: 000399955500030 | en_US |
dc.description | PubMed ID: 27781272 | en_US |
dc.description.abstract | Background and ObjectiveThe aim of this study was to evaluate the effect of nonsurgical periodontal therapy on clinical parameters and gingival crevicular fluid levels of tissue/blood vessel-type plasminogen activator (t-PA) and plasminogen activator inhibitor-2 (PAI-2) in patients with periodontitis, with or without rheumatoid arthritis (RA). Material and MethodsFifteen patients with RA and chronic periodontitis (RA-P), 15 systemically healthy patients with chronic periodontitis (H-P) and 15 periodontally and systemically healthy volunteers (C) were included in the study. Plaque index, gingival index, probing pocket depth, clinical attachment level, bleeding on probing, gingival crevicular fluid t-PA and PAI-2 levels, erythrocyte sedimentation rate, serum C-reactive protein and disease activity score were evaluated at baseline and 3 mo after mechanical nonsurgical periodontal therapy. ResultsAll periodontal clinical parameters were significantly higher in the RA-P and H-P groups compared with the C group (p < 0.001) and decreased significantly after treatment (p < 0.001). Pretreatment t-PA levels were highest in the RA-P group and significantly decreased post-treatment (p = 0.047). Pre- and post-treatment PAI-2 levels were significantly lower in controls compared with both periodontitis groups (p < 0.05). Gingival crevicular fluid volume and the levels of t-PA and PAI-2 were significantly correlated. ConclusionIn patients with periodontitis and RA, nonsurgical periodontal therapy reduced the pretreatment gingival crevicular fluid t-PA levels, which were significantly correlated with gingival crevicular fluid PAI-2 levels. The significantly higher t-PA and PAI-2 gingival crevicular fluid levels in periodontal patients, regardless of systemic status, suggest that the plasminogen activating system plays a role in the disease process of periodontitis. | en_US |
dc.description.sponsorship | Ankara University Scientific Research Projects Office, Ankara, Turkey [08B3334005] | en_US |
dc.description.sponsorship | This study was supported by the Ankara University Scientific Research Projects Office, Ankara, Turkey (08B3334005). The authors declare that they have no conflicts of interest. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Gingival Crevicular Fluid | en_US |
dc.subject | Periodontitis | en_US |
dc.subject | Plasminogen Activator Inhibitor-2 | en_US |
dc.subject | Rheumatoid Arthritis | en_US |
dc.subject | Tissue Plasminogen Activator | en_US |
dc.title | Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: Effects of nonsurgical periodontal therapy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Periodontal Research | en_US |
dc.department | İstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-7986-7085 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 574 | en_US |
dc.identifier.endpage | 581 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/jre.12425 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q2 | en_US |