Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus
MetadataShow full item record
CitationÖnal, Z., Ersen, A., Bayramoğlu, E., Kazancı Yaroğlu, S., Önal, H. ve Adal, E. (2016). Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus. Journal Of Pediatric Endocrinology & Metabolism, 29(9), 1013-1017. https://dx.doi.org/10.1515/jpem-2015-0211
Background: Type 1 diabetes mellitus (T1DM) is speculated to have an impaired immunological response to vaccines. This paper aimed to investigate the presence of specific antibodies against hepatitis B virus (HBV) and measles in diabetic children who had been immunized according to the standard national calendar of immunization. Methods: Two hundred and one diabetic children and 140 healthy controls were prospectively evaluated. Antibodies against hepatitis B (anti-HBs) and measles were detected in all individuals who completed the vaccination schedule. We noted onset of T1DM, duration of the disease, diabetes-related autoantibodies and mean HbA(1c) levels. Results: Some 72.6% of diabetics and 82.1% of controls had anti-HBs (+) (p=0.04). We found a reduced efficacy of measles vaccination in anti-HBs (-) diabetic children (p=0.009), even though there was no significant difference between the study and control groups. Onset of the disease was earlier in anti-HBs (-) diabetics than in controls (p=0.038). No difference with respect to other parameters was found. Conclusions: Our data showed a reduced seroprotection rate for HBV vaccination in diabetic children and for measles with anti-HBs (-) diabetics. Larger studies should be encouraged to confirm the vaccine efficacy in diabetic children and to elucidate possible pathogenic mechanisms.