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dc.contributor.authorCengiz, Nurettin
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorErdoǧan, Ender
dc.contributor.authorHim, Aydın
dc.contributor.authorOğuz, Elif Kaval
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:47Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:47Z
dc.date.issued2012en_US
dc.identifier.citationCengiz, N., Öztürk, G., Erdoǧan, E., Him, A. ve Oğuz, E.(2012). Consequences of neurite transection in vitro. Journal of Neurotrauma, 29(15), 2465-2474. https://dx.doi.org/10.1089/neu.2009.0947en_US
dc.identifier.issn0897-7151
dc.identifier.urihttps://dx.doi.org/10.1089/neu.2009.0947
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3227
dc.descriptionWOS: 000309967300004en_US
dc.descriptionPubMed ID: 20121423en_US
dc.description.abstractIn order to quantify degenerative and regenerative changes and analyze the contribution of multiple factors to the outcome after neurite transection, we cultured adult mouse dorsal root ganglion neurons, and with a precise laser beam, we transected the nerve fibers they extended. Cell preparations were continuously visualized for 24 h with time-lapse microscopy. More distal cuts caused a more elongated field of degeneration, while thicker neurites degenerated faster than thinner ones. Transected neurites degenerated more if the uncut neurites of the same neuron simultaneously degenerated. If any of these uncut processes regenerated, the transected neurites underwent less degeneration. Regeneration of neurites was limited to distal cuts. Unipolar neurons had shorter regeneration than multipolar ones. Branching slowed the regenerative process, while simultaneous degeneration of uncut neurites increased it. Proximal lesions, small neuronal size, and extensive and rapid neurite degeneration were predictive of death of an injured neuron, which typically displayed necrotic rather than apoptotic form. In conclusion, this in vitro model proved useful in unmasking many new aspects and correlates of mechanically-induced neurite injury.en_US
dc.description.sponsorshipYuzuncu Yil University Directorate of Scientific Research Projects [TF073]en_US
dc.description.sponsorshipThis study was supported by the Yuzuncu Yil University Directorate of Scientific Research Projects (grant no. TF073).en_US
dc.language.isoengen_US
dc.publisherMary Ann Liebert Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxonal Injuryen_US
dc.subjectAxonal Regenerationen_US
dc.subjectDegenerationen_US
dc.subjectNeuronal Cell Deathen_US
dc.titleConsequences of neurite transection in vitroen_US
dc.typearticleen_US
dc.relation.journalJournal of Neurotraumaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-0352-1947en_US
dc.identifier.volume29en_US
dc.identifier.issue15en_US
dc.identifier.startpage2465en_US
dc.identifier.endpage2474en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1089/neu.2009.0947en_US


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