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dc.contributor.authorBaşkan, Özdil
dc.contributor.authorSılav, Gökalp
dc.contributor.authorSarı, Ramazan
dc.contributor.authorCanöz, Özlem
dc.contributor.authorElmacı, İlhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:36Z
dc.date.issued2015en_US
dc.identifier.citationBaşkan, Ö., Sılav, G., Sarı, R., Canöz, Ö. ve Elmacı, İ. (2015). Relationship of intraoperative ultrasound characteristics with pathological grades and Ki-67 proliferation index in intracranial gliomas. Journal of Medical Ultrasonics, 42(2), 231-237. https://dx.doi.org/10.1007/s10396-014-0593-1en_US
dc.identifier.issn1346-4523
dc.identifier.issn1613-2254
dc.identifier.urihttps://dx.doi.org/10.1007/s10396-014-0593-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3198
dc.descriptionWOS: 000352689100012en_US
dc.descriptionPubMed ID: 26576577en_US
dc.description.abstractThe purpose of the present study was to investigate the relationship between the intraoperative ultrasonographic appearances and the histopathological characteristics of glial tumors using the pathological grading system and the Ki-67 proliferation index. Patients with glial tumors who underwent surgery with the aid of intraoperative ultrasonography (IOUS) between September 2013 and August 2014 were included in the study. The lesions' IOUS characteristics were analyzed and compared with the results of surgical histopathological characteristics. Lesions were classified as low-grade gliomas (grade I-II, LGG) and high-grade gliomas (grade III-IV, HGG). The glioblastoma multiforme (grade IV, GBM) group was classified according to the Ki-67 values for further evaluation. The Chi square test (Fisher's exact test) was used for comparing the ultrasonographic characteristics of the low-grade and high-grade gliomas; HGG with different Ki-proliferation indexes. A value of P < 0.05 was considered statistically significant. A total of 41 patients were included. The histopathological findings revealed 15 LGG and 26 HGG. Twenty of the 26 HGG were GBM. Differences were found between the intraoperative ultrasonographic characteristics of the low-grade and high-grade glial tumors. The majority of LGGs were mildly hyperechoic and homogeneous, with distinct margins and a regular contour. HGGs were mostly highly hyperechoic, with indistinct margins, irregular contours, and a heterogeneous internal texture. Surrounding edema was seen more often in HGGs. The differences in the echogenicity of the solid parts, the internal echo patterns, margins, contours, and peripheral edema (P < 0.05) were statistically significant, but the difference in the presence of cysts (P > 0.05) was not significant. In the GBM group, all of the lesions with distinct margins and regular contours had Ki-67 values a parts per thousand currency sign15 %. We compared the intraoperative ultrasonographic characteristics of the Ki-67 > 15 % group with those of the Ki-67 a parts per thousand currency sign 15 % group for statistical significance. The difference between the echogenicity of the solid parts, margins, and contours was statistically significant between the groups (P < 0.05). The difference in the internal echo pattern, presence of cyst, and peripheral edema was insignificant (P > 0.05). IOUS is a very useful imaging technique not only in defining the borders but also in characterizing the tumoral tissue. The IOUS characteristics of the glial tumors were a valuable tool in differentiating the grades of the glial tumors and might have a relationship with the Ki-67 proliferation index. We think this theory requires further investigation in more detailed comparative studies with larger numbers of patients.en_US
dc.language.isoengen_US
dc.publisherSpringer Japanen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectJournal of Medical Ultrasonicsen_US
dc.subjectGlial Tumorsen_US
dc.subjectHistopathologyen_US
dc.subjectGradeen_US
dc.subjectKi-67en_US
dc.titleRelationship of intraoperative ultrasound characteristics with pathological grades and Ki-67 proliferation index in intracranial gliomasen_US
dc.typearticleen_US
dc.relation.journalJournal of Medical Ultrasonicsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7866-8113en_US
dc.authorid0000-0001-9433-0307en_US
dc.identifier.volume42en_US
dc.identifier.issue2en_US
dc.identifier.startpage231en_US
dc.identifier.endpage237en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10396-014-0593-1en_US


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