dc.contributor.author | Koplay, Mustafa | |
dc.contributor.author | Doğan, Nasuh Utku | |
dc.contributor.author | Erdoğan, Hasan | |
dc.contributor.author | Sivri, Mesut | |
dc.contributor.author | Erol, Cengiz | |
dc.contributor.author | Nayman, Alaaddin | |
dc.contributor.author | Karabağlı, Pınar | |
dc.contributor.author | Paksoy, Yahya | |
dc.contributor.author | Çelik, Çetin | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:58:35Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:58:35Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Koplay, M., Doğan, N. U., Erdoğan, H., Sivri, M., Erol, C., Nayman, A. ... Çelik, Ç. (2014). Diagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinoma. Journal of Medical Imaging and Radiation Oncology, 58(5), 538-546. https://dx.doi.org/10.1111/1754-9485.12209 | en_US |
dc.identifier.issn | 1754-9477 | |
dc.identifier.issn | 1754-9485 | |
dc.identifier.uri | https://dx.doi.org/10.1111/1754-9485.12209 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3195 | |
dc.description | WOS: 000345630000003 | en_US |
dc.description | PubMed ID: 25046775 | en_US |
dc.description.abstract | Introduction: To determine the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) for the pre-operative assessment of patients with endometrial carcinoma and to assess myometrial and cervical invasion as well as pelvic lymph node metastasis. Methods: Fifty-eight women who underwent surgery for histopathologically confirmed endometrial carcinoma were included in the current study. Prior to surgery, patients were evaluated using pelvic DW-MRI and gadolinium-enhanced T1-weighted imaging (Gd-T1WI). Gd-T1WI was evaluated together with T2-weighted images. DW-MR images were obtained in the axial plane using echo-planar spin-echo pulse sequences with different b factors. Endometrial carcinomas were observed as areas of increased intensity on DW-MRI images, and their intensity was compared with the surrounding hypo-intense myometrium. Pre-operative DW-MRI and Gd-T1WI results were compared with post-operative histopathological findings that served as reference standards. Results: The sensitivity, specificity, positive (PPV) and negative predictive values (NPV), and diagnostic accuracy of DW-MRI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 89%, 81%, 92% and 88%, respectively. The sensitivity, specificity and diagnostic accuracy rates were 82%, 91% and 89.6% for cervical invasion and 100%, 96% and 96.5% for pelvic lymph node metastasis, respectively. The sensitivity, specificity, PPV and NPV, and diagnostic accuracy of Gd-T1WI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 81.5%, 71%, 91% and 83%, respectively. The sensitivity, specificity and diagnostic accuracy were 73%, 89% and 86% for cervical invasion, respectively. Conclusions: These findings suggest that DW-MRI may be a good diagnostic tool with high sensitivity and specificity for assessing myometrial invasion and detecting tumour extension. We suggest that DW-MRI should be considered as a routine part of the pre-operative pelvic MRI in all patients with endometrial carcinoma. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Diffusion-Weighted Imaging | en_US |
dc.subject | Endometrial Carcinoma | en_US |
dc.subject | MRI | en_US |
dc.subject | Staging | en_US |
dc.title | Diagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinoma | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Medical Imaging and Radiation Oncology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-3468-7712 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 538 | en_US |
dc.identifier.endpage | 546 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/1754-9485.12209 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q2 | en_US |