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dc.contributor.authorKoplay, Mustafa
dc.contributor.authorDoğan, Nasuh Utku
dc.contributor.authorErdoğan, Hasan
dc.contributor.authorSivri, Mesut
dc.contributor.authorErol, Cengiz
dc.contributor.authorNayman, Alaaddin
dc.contributor.authorKarabağlı, Pınar
dc.contributor.authorPaksoy, Yahya
dc.contributor.authorÇelik, Çetin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:35Z
dc.date.issued2014en_US
dc.identifier.citationKoplay, M., Doğan, N. U., Erdoğan, H., Sivri, M., Erol, C., Nayman, A. ... Çelik, Ç. (2014). Diagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinoma. Journal of Medical Imaging and Radiation Oncology, 58(5), 538-546. https://dx.doi.org/10.1111/1754-9485.12209en_US
dc.identifier.issn1754-9477
dc.identifier.issn1754-9485
dc.identifier.urihttps://dx.doi.org/10.1111/1754-9485.12209
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3195
dc.descriptionWOS: 000345630000003en_US
dc.descriptionPubMed ID: 25046775en_US
dc.description.abstractIntroduction: To determine the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) for the pre-operative assessment of patients with endometrial carcinoma and to assess myometrial and cervical invasion as well as pelvic lymph node metastasis. Methods: Fifty-eight women who underwent surgery for histopathologically confirmed endometrial carcinoma were included in the current study. Prior to surgery, patients were evaluated using pelvic DW-MRI and gadolinium-enhanced T1-weighted imaging (Gd-T1WI). Gd-T1WI was evaluated together with T2-weighted images. DW-MR images were obtained in the axial plane using echo-planar spin-echo pulse sequences with different b factors. Endometrial carcinomas were observed as areas of increased intensity on DW-MRI images, and their intensity was compared with the surrounding hypo-intense myometrium. Pre-operative DW-MRI and Gd-T1WI results were compared with post-operative histopathological findings that served as reference standards. Results: The sensitivity, specificity, positive (PPV) and negative predictive values (NPV), and diagnostic accuracy of DW-MRI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 89%, 81%, 92% and 88%, respectively. The sensitivity, specificity and diagnostic accuracy rates were 82%, 91% and 89.6% for cervical invasion and 100%, 96% and 96.5% for pelvic lymph node metastasis, respectively. The sensitivity, specificity, PPV and NPV, and diagnostic accuracy of Gd-T1WI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 81.5%, 71%, 91% and 83%, respectively. The sensitivity, specificity and diagnostic accuracy were 73%, 89% and 86% for cervical invasion, respectively. Conclusions: These findings suggest that DW-MRI may be a good diagnostic tool with high sensitivity and specificity for assessing myometrial invasion and detecting tumour extension. We suggest that DW-MRI should be considered as a routine part of the pre-operative pelvic MRI in all patients with endometrial carcinoma.en_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDiffusion-Weighted Imagingen_US
dc.subjectEndometrial Carcinomaen_US
dc.subjectMRIen_US
dc.subjectStagingen_US
dc.titleDiagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinomaen_US
dc.typearticleen_US
dc.relation.journalJournal of Medical Imaging and Radiation Oncologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-3468-7712en_US
dc.identifier.volume58en_US
dc.identifier.issue5en_US
dc.identifier.startpage538en_US
dc.identifier.endpage546en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/1754-9485.12209en_US


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