dc.contributor.author | Karaman, Adem | |
dc.contributor.author | Durur Subaşı, Irmak | |
dc.contributor.author | Alper, Fatih | |
dc.contributor.author | Durur Karakaya, Afak | |
dc.contributor.author | Subaşı, Mahmut | |
dc.contributor.author | Akgün, Metin | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:58:30Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:58:30Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Karaman, A., Durur Subaşı, I., Alper, F., Durur Karakaya, A., Subaşı, M. ve Akgün, M. (2017). Is it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results. Journal of Magnetic Resonance Imaging, 46(4), 1001-1006. https://dx.doi.org/10.1002/jmri.25649 | en_US |
dc.identifier.issn | 1053-1807 | |
dc.identifier.issn | 1522-2586 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jmri.25649 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3181 | |
dc.description | WOS: 000410309300006 | en_US |
dc.description | PubMed ID: 28152254 | en_US |
dc.description.abstract | Purpose: To determine whether the use of necrosis/wall apparent diffusion coefficient (ADC) ratios in the differentiation of necrotic lung lesions is more reliable than measuring the wall alone. Materials and Methods: In this retrospective study, a total of 76 patients (54 males and 22 females, 71% vs. 29%, with a mean age of 53 +/- 18 years, range, 18-84) were enrolled, 33 of whom had lung carcinoma and 43 had a benign necrotic lung lesion. A 3T scanner was used. The calculation of the necrosis/wall ADC ratio was based on ADC values measured from necrosis and the wall of the lesions by diffusion-weighted imaging (DWI). Statistical analyses were performed with the independent samples t-test and receiver operating characteristic analysis. Intraobserver and interobserver reliability were calculated for ADC values of wall and necrosis. Results: The mean necrosis/wall ADC ratio was 1.67 +/- 0.23 for malignant lesions and 0.75 +/- 0.19 for benign lung lesions (P < 0.001). To estimate malignancy the area under the curve (AUC) values for necrosis ADC, wall ADC, and the necrosis/wall ADC ratio were 0.720, 0.073, and 0.997, respectively. A wall/necrosis ADC ratio cutoff value of 1.12 demonstrated a 100% sensitivity and 98% specificity in the estimation of malignancy. Positive predictive value was 100%, and negative predictive value 98% and diagnostic accuracy 99%. There was a good intraobserver and interobserver reliability for wall and necrosis. Conclusion: The necrosis/wall ADC ratio appears to be a reliable and promising tool for discriminating lung carcinoma from benign necrotic lung lesions than measuring the wall alone. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Necrosis | en_US |
dc.subject | Apparent Diffusion Coefficient (ADC) | en_US |
dc.subject | Measurements | en_US |
dc.subject | Necrosis/Wall | en_US |
dc.subject | ADC Ratio | en_US |
dc.subject | Malignant and Benign Necrotic Lung Lesions | en_US |
dc.subject | Preliminary Results | en_US |
dc.title | Is it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Magnetic Resonance Imaging | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 1001 | en_US |
dc.identifier.endpage | 1006 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/jmri.25649 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |