Synthesis and anti-cancer activity evaluation of new aurone derivatives
Gündoğdu Karaburun, Nalan
Karaburun, Ahmet Çağrı
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CitationDemirayak, Ş., Yurttaş, L., Gündoğdu Karaburun, N., Karaburun, A. Ç. ve Kayagil, İ. (2015). Synthesis and anti-cancer activity evaluation of new aurone derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(5), 816-825. https://dx.doi.org/10.3109/14756366.2014.976568
In this study, we have synthesized 2-[3-or 4-(2-aryl-2-oxoethoxy) arylidene] benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions using benzofuranon-3-one derivatives (A1-A4, B) as starting materials which were gained in various synthetic ways. Aurone derivatives (C1-C10) were acquired with the condensation reaction of these starting materials and 3-/4-hydroxybenzaldehyde which were then reacted with a-bromoacetophenones to get final compounds. The anti-cancer activity of the selected compounds was performed by National Cancer Institute (NCI), USA against 60 human tumor cell lines derived from nine neoplastic diseases. Compounds exhibited anti-cancer activity in varying ratios.