Show simple item record

dc.contributor.authorKaya, Zehra
dc.contributor.authorÇağlayan, Sinan
dc.contributor.authorAkkiprik, Mustafa
dc.contributor.authorAral, Cenk
dc.contributor.authorÖzışık, Gökhan
dc.contributor.authorÖzata, Metin
dc.contributor.authorÖzer, Ayşe
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:01Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:01Z
dc.date.issued2016en_US
dc.identifier.citationKaya, Z., Çağlayan, S., Akkiprik, M., Aral, C., Özışık, G., Özata, M. ... Özer, A. (2016). Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome. Journal Of Endocrinological Investigation, 39(5), 557-566. https://dx.doi.org/10.1007/s40618-015-0409-1en_US
dc.identifier.issn1720-8386
dc.identifier.urihttps://dx.doi.org/10.1007/s40618-015-0409-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3092
dc.descriptionWOS: 000374102700010en_US
dc.descriptionPubMed ID: 26596278en_US
dc.description.abstractBackground The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS. Materials and methods Seventy subjects with MetS and 185 healthy controls were enrolled in the study. PCR-RFLP analysis was used for genotyping. Results for each polymorphism have been verified by allele-specific oligonucleotide analysis. Results BclI GG genotype was significantly associated with an increased risk of MetS (p = 0.02). Also, only in women, the G allele carriers were significantly associated with higher C-peptide. T allele carriers of TthIII1 polymorphism were significantly associated with higher C-peptide, triglyceride, insulin and C-reactive protein (CRP, p value 0.048, 0.022, 0.005 and 0.022, respectively), and lower fasting blood glucose (FBG, p = 0.02). The combined carriers of BclI polymorphism G allele and TthIII1 polymorphism T allele were significantly associated with higher diastolic blood pressure in all patients, and lower FBG and postprandial blood glucose in only men. All the ER22/23EK polymorphisms coexisted with polymorphic variant of TthIII1 (p = 0.0058). Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [104S272, SBAG-K-60]; Research Foundation of Marmara University (BAPKO) [SAG-C-DRP-101011-0286]en_US
dc.description.sponsorshipThe authors appreciate Dr. Can Erzik for his critical revision of the manuscript. This work was partly supported by a grant (104S272, SBAG-K-60 to SC) from the Scientific and Technological Research Council of Turkey (TUBITAK) and grants (SAG-C-DRP-101011-0286 to AO) from the Research Foundation of Marmara University (BAPKO).en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectGlucocorticoid Receptor Geneen_US
dc.subjectGlucocorticoiden_US
dc.titleImpact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndromeen_US
dc.typearticleen_US
dc.relation.journalJournal Of Endocrinological Investigationen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-3636-3853en_US
dc.identifier.volume39en_US
dc.identifier.issue5en_US
dc.identifier.startpage557en_US
dc.identifier.endpage566en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s40618-015-0409-1en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record