Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults
Citation
Üstüner, P., Balevi, E. ve Özdemir, M. (2017). Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults. Journal of Dermatological Treatment, 28(8), 753-761. https://dx.doi.org/10.1080/09546634.2017.1329497Abstract
Purpose: To evaluate and compare the clinical efficacy, dermoscopic results and safety of triamcinolone acetonide (TA) and betamethasone dipropionate (BD) injections at different concentrations in localized scalp and beard alopecia. Methods: Intralesional injection of BD or TA in three different dilutions; 1/4, 1/8, 1/12 (BD1, BD2, BD3, TA1, TA2, TA3) and Saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients every four weeks in a maximum of six sessions until a hair regrowth score of 4 was achieved. The number of required sessions, sixth-month hair regrowth scores, treatment success rates and dermoscopic data were investigated. Results: The mean number of required sessions were similar and significantly lower in BD1 and TA1 being 4.21 +/- 1.12 and 3.74 +/- 0.99, respectively. Dermoscopic examinations revealed similar terminal hair growth rations in Saline (30.3%), BD1 (44.4%) and TA1 (42.9%). However, sixth-month hair regrowth scores, overall treatment success rates and percentage of terminal hair regrowth were similar in BD1 and TA1. However, adverse effects were more common in TA groups (24.3%) than in BD groups (10.6%) at the sixth month. Conclusions: BD 1= 4 dilution (1.25 mg/dL) seems best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults.
WoS Q Kategorisi
Q2xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q1Source
Journal of Dermatological TreatmentVolume
28Issue
8Collections
- Makale Koleksiyonu [3441]
- PubMed İndeksli Yayınlar Koleksiyonu [3748]
- Scopus İndeksli Yayınlar Koleksiyonu [5788]
- WoS İndeksli Yayınlar Koleksiyonu [5966]