Basit öğe kaydını göster

dc.contributor.authorGüven, Gökhan
dc.contributor.authorGültekin, Bahattin Alper
dc.contributor.authorGüven Şenol, Gamze
dc.contributor.authorGüzel, Elif
dc.contributor.authorFurat, Selenay
dc.contributor.authorErsanlı, Selim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:53Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:53Z
dc.date.issued2016en_US
dc.identifier.citationGüven, G., Gültekin, B. A., Güven Şenol, G., Güzel, E., Furat, S. ve Ersanlı, S. (2016). Histologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-BB in experimental groups. Journal Of Craniofacial Surgery, 27(3), 805-809. https://dx.doi.org/10.1097/SCS.0000000000002560en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000002560
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3065
dc.descriptionWOS: 000376992200102en_US
dc.descriptionPubMed ID: 27092911en_US
dc.description.abstractEfficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered via absorbable collagen sponge (ACS) on bone formation was evaluated in guinea pig tibias. Three-millimeter-circular bone tibia defects were created in 24 guinea pigs assigned randomly to 4 groups according to the following defect filling materials: ACS only, rhBMP-2_ACS, rhPDGF-BB_ACS, or empty. New bone formation was evaluated histologically and histomorphometrically at 15 (early healing) and 45 days (late healing). Mean new bone per total defect area ratio was 0.73, 0.57, 0.43, and 0.42 in rhBMP-2_ACS, rhPDGF-BB_ACS, ACS only, and empty groups at early healing, respectively. During early healing, significantly more new bone formation was observed in rhBMP-2_ACS and rhPDGF-BB_ACS groups than in the control groups. New bone formation was significantly higher with rhBMP-2_ACS than with rhPDGF-BB_ACS. Mean new bone per total defect area ratio was 0.81, 0.86, 0.74, and 0.75 in the rhBMP2_ACS, rhPDGF-BB_ACS, ACS only, and empty groups at late healing, respectively. During late healing, new bone formation was significantly higher in the rhPDGF-BB_ACS group relative to both control groups, but the results did not differ significantly from those in the rhBMP-2_ACS group. New bone formation in the rhBMP2_ACS group did not change significantly between the healing periods. In the rhPDGF-BB_ACS group, however, new bone formation was significantly higher in the late healing period. Both growth factors accelerated new bone formation in the early healing period. Although rhBMP-2 was more effective in the early healing period, the effects of rhPDGF-BB were longer lasting.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [2013-10]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project 2013-10).en_US
dc.language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAbsorbable Collagen Spongeen_US
dc.subjectBone Regenerationen_US
dc.subjectGuinea Pigen_US
dc.subjectRHBMP-2en_US
dc.subjectRhPDGF-BBen_US
dc.titleHistologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-BB in experimental groupsen_US
dc.typearticleen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.identifier.volume27en_US
dc.identifier.issue3en_US
dc.identifier.startpage805en_US
dc.identifier.endpage809en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1097/SCS.0000000000002560en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster