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dc.contributor.authorDoğan, Remzi
dc.contributor.authorErtaş, Burak
dc.contributor.authorÖzüçer, Berke
dc.contributor.authorBirday, Erkingül
dc.contributor.authorÖzturan, Orhan
dc.contributor.authorVeyseller, Bayram
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:52Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:52Z
dc.date.issued2017en_US
dc.identifier.citationDoğan, R., Ertaş, B., Özüçer, B., Birday, E., Özturan, O. ve Veyseller, B. (2017). Olfactory dysfunction associated with Neuro-Behcet disease. Journal of Craniofacial Surgery, 28(7), E707-E710. https://dx.doi.org/10.1097/SCS.0000000000003928en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000003928
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3062
dc.descriptionWOS: 000417057300044en_US
dc.descriptionPubMed ID: 28863008en_US
dc.description.abstractIntroduction: Neurologic involvement associated with Behcet disease (BD) is defined as a different entity: Neuro-Behcet disease (NBD). Behcet disease presents with olfactory dysfunction. It is not known whether this is the consequence of mucosal involvement or neurologic involvement. Objective: The aim of this study was to investigate whether olfactory dysfunction was further aggravated as the result of neurologic involvement. Methods: Sixteen patients diagnosed with NBD and 16 healthy control patients with similar demographic characteristics were recruited as the healthy control group. Expanded Disability Status Scale (EDSS) scoring was used for quantification of neurological disability. All diagnoses were confirmed and categorized with magnetic resonance imaging studies in all patients individually: parenchymal or nonparenchymal. A well-established test of orthonasal olfaction developed at the CCCRC was used. Correlation analysis was carried out. Results: The mean CCCRC score of NBD patients was 4.60 out of 7, and this group was diagnosed to bemoderately hyposmic, whereas the average score of the control group was 6.5; the difference was significant (P< 0.0001). CCCRC scores of NBD patients were significantly lower compared both healthy control patients and those of BD patients reported in the literature. Mean EDSS score of NBD patients was 1.75 +/- 1.0 out of 10 (0-no neurologic disability and 10-worst neurologic disability). Magnetic resonance imaging of NBD patients revealed 4 nonparenchymal and 12 parenchymal patients. Neuro-Behc, et disease patients with parenchymal involvement presented with (worse) EDSS scores. Mean olfactory CCCRC score of this group was 4.38 whereas the average olfactory score of the vascular group was 5.25 out 7. Average EDSS score of vascular group was 0.75, much better compared to higher average neurologic disability score of 2.08 for the parenchymal group. Significant correlation existed between the duration of NBD and both olfactory and neurologic dysfunction scores. Conclusion: Neuro-Behc, et disease present with aggravated olfactory dysfunction compared to BD. Neurologic involvementespecially parenchymal involvement-seems to deteriorate the olfactory dysfunction. Duration of disease is correlated with this severity of dysfunction.en_US
dc.language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBehceten_US
dc.subjectCCCRCen_US
dc.subjectEDSSen_US
dc.subjectNeuro-Behceten_US
dc.subjectOlfactionen_US
dc.subjectOlfactory Dysfunctionen_US
dc.subjectOlfactory Functionen_US
dc.titleOlfactory dysfunction associated with Neuro-Behcet diseaseen_US
dc.typearticleen_US
dc.relation.journalJournal of Craniofacial Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.identifier.volume28en_US
dc.identifier.issue7en_US
dc.identifier.startpageE707en_US
dc.identifier.endpageE710en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1097/SCS.0000000000003928en_US


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