dc.contributor.author | Sili, Uluhan | |
dc.contributor.author | Kaya, Abdurrahman | |
dc.contributor.author | Aydın, Selda | |
dc.contributor.author | Hondur, Nur | |
dc.contributor.author | Mert, Ali | |
dc.contributor.author | Tabak, Fehmi | |
dc.contributor.author | Özaras, Reşat | |
dc.contributor.author | Öztürk, Recep | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:57:45Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:57:45Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Sili, U., Kaya, A., Aydın, S., Hondur, N., Mert, A., Tabak, F. ... Öztürk, R. (2015). HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA. Journal of Clinical Virology, 67, 73-77. https://dx.doi.org/10.1016/j.jcv.2015.04.014 | en_US |
dc.identifier.issn | 1386-6532 | |
dc.identifier.issn | 1873-5967 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.jcv.2015.04.014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3042 | |
dc.description | WOS: 000354124400016 | en_US |
dc.description | PubMed ID: 25959163 | en_US |
dc.description.abstract | Background: Hepatitis C virus (HCV) status cannot be reliably predicted in anti-HCV positive/HCV-RNA negative individuals who may either have recovered spontaneously or have a false-positive test due to antibody cross-reaction. Investigating T lymphocyte responses in individuals with different HCV status may help understand the cellular immune mechanisms underlying spontaneous recovery, treatment response, and chronicity. Objective: We aimed to determine whether anti-HCV positive, HCV-RNA negative individuals are truly spontaneous recoverers from acute HCV infection. Study design: We used enzyme-linked immunosorbent spot (ELISPOT) assay to compare HCV-specific lymphocyte response among anti-HCV positive/HCV-RNA negative individuals, patients with sustained virological response to interferon-gamma/ribavirin treatment, and patients with chronic HCV infection. Results: We found that 83% of anti-HCV positive/HCV-RNA negative individuals without a past medical history of acute icteric hepatitis had an HCV-specific T lymphocyte response in peripheral blood. Lymphocyte responses in these individuals were similar in magnitude to treatment responders unlike patients with chronic HCV whose virus-directed immunity was significantly suppressed. Conclusions: Detection of HCV-specific T lymphocyte responses using ELISPOT is a feasible method to ascertain past asymptomatic acute HCV infection. | en_US |
dc.description.sponsorship | Office of Scientific Research Projects, Istanbul University [BYPS-1-26/31012007] | en_US |
dc.description.sponsorship | This study is funded in part by the Office of Scientific Research Projects, Istanbul University (no: BYPS-1-26/31012007). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | HCV | en_US |
dc.subject | T-lymphocyte | en_US |
dc.subject | Spontaneous Recovery | en_US |
dc.subject | Elispot | en_US |
dc.subject | False-Positive Serology | en_US |
dc.title | HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Clinical Virology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-8945-2385 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.startpage | 73 | en_US |
dc.identifier.endpage | 77 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.jcv.2015.04.014 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |