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dc.contributor.authorTural, Deniz
dc.contributor.authorYıldız, Özcan
dc.contributor.authorElçin, Olgun
dc.contributor.authorErdamar, Sibel
dc.contributor.authorGüney, Sabri
dc.contributor.authorDemireli, Fuat
dc.contributor.authorBüyükünal, Evin
dc.contributor.authorSerdengeçti, Süheyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:30Z
dc.date.issued2014en_US
dc.identifier.citationTural, D., Yıldız, Ö., Elçin, O., Erdamar, S., Güney, S. Demireli, F. ... Serdengeçti, S. (2014). What is the optimal treatment in clinical stage T3N0M0 rectal cancer? Journal of the Balkan Union of Oncology, 19(1), 97-102.en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2991
dc.descriptionWOS: 000334153000014en_US
dc.descriptionPubMed ID: 24659649en_US
dc.description.abstractPurpose: Some previous studies suggested that certain rectal cancer patients with stage T3N0 and favorable features may be adequately treated with surgery and adjuvant chemotherapy. However, the optimal management of clinical (c) T3N0 rectal adenocarcinoma based on preoperative imaging is unclear. In this study, we aimed to determine the frequency of lymph node metastases in patients clinically staged as T3N0 rectal adenocarcinoma following preoperative chemoradiotherapy (CTR). Methods: The medical records of 105 patients with clinico-imaging stage T3N0M0 rectal cancer who received preoperative CRT between 2004-2011 were retrospectively analyzed. Chemotherapy used concurrently with preoperative radiotherapy (RT) was protracted 5-fluorouracil (5FU) infusion. Results: Twenty-seven percent of the patients clinically staged as T3N0 before preoperative CRT had pathological (p) lymph node involvement on surgical material. The rate of pathological lymph node involvement was 0% in pT1, 20% in pT2, 35% in pT3 and 34% in pT4 patients. A significant association was demonstrated between pT stages and pN status (p=-0.03). Conclusion: Our study demonstrated that the accuracy of preoperative imaging for staging rectal cancer is limited because at least 27% of the patients may have undetected lymph node involvement after preoperative CRT in surgical material.en_US
dc.language.isoengen_US
dc.publisherZerbinis Medical Publicationsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClinical T3en_US
dc.subjectN0 Rectal Adenocarcinomaen_US
dc.subjectPreoperative Imagingen_US
dc.subjectUnderstageden_US
dc.titleWhat is the optimal treatment in clinical stage T3N0M0 rectal cancer?en_US
dc.typearticleen_US
dc.relation.journalJournal of the Balkan Union of Oncologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume19en_US
dc.identifier.issue1en_US
dc.identifier.startpage97en_US
dc.identifier.endpage102en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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