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Clinical importance of discordance of hormone receptors and Her2/neu status after neoadjuvant chemotherapy in breast cancer

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info:eu-repo/semantics/openAccess

Date

2014

Author

Öven Ustaalioğlu, Bala Başak
Aker Vardar, Fügen
Bilici, Ahmet
Gürleyik, Günay
Erkol, Burçak
Kefeli, Umut
Aliustaoglu, Mehmet

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Citation

Öven Ustaalioğlu, B. B., Aker Vardar, F., Bilici, A., Gürleyik, G., Erkol, B., Kefeli, U. ... Aliustaoglu, M. (2014). Clinical importance of discordance of hormone receptors and Her2/neu status after neoadjuvant chemotherapy in breast cancer. Journal of the Balkan Union of Oncology, 19(4). 879-886.

Abstract

Purpose: The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between core needle biopsy (CNB) and residual tumor after surgery of breast cancer treated with neoadjuvant chemotherapy (NAC), and also to evaluate the impact of discordance and other clinicopathological factors on survival. Methods: Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry (IHC) on 90 CNBs of primary tumors and surgical specimens after NAC (study group); 53 patients without NAC served as control group, and discordance was compared between the two groups. The association between discordance of HR status after NAC and various other clinicopathological factors was tested with Spearman's test. Results: Pathological complete response (PCR) was achieved in 10 (11.1%) patients after NAC. ER and PR changed significantly more in the study than in the control group. ER and PR discordance was detected in 10 (12.5%) and 17 (21.2%) patients in the NAC group and in 1 (1.8%) and 2 (3.7%) patients in the control group (p=0.04 and p=0.005, respectively). ER discordance was related with HER2/neu change. Furthermore, PR discordance correlated with CNB, ER and treatment response, while HER2/neu discordance was associated with treatment response (p=0.05). ER discordance was found to be an independent prognostic factor for progression-free survival (PFS) (p=0.02). Conclusion: NAC might cause alterations in ER, PR or HER2/neu status in breast cancer, and they should be re-tested in the residual tumor after NAC to optimize adjuvant therapy.

WoS Q Kategorisi

Q4

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q3

Source

Journal of the Balkan Union of Oncology

Volume

19

Issue

4

URI

https://hdl.handle.net/20.500.12511/2989

Collections

  • Makale Koleksiyonu [3452]
  • PubMed İndeksli Yayınlar Koleksiyonu [3764]
  • Scopus İndeksli Yayınlar Koleksiyonu [5808]



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