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dc.contributor.authorEryılmaz, Oğuz
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorBay, Sadık
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorAkalın, Mehmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:25Z
dc.date.issued2018en_US
dc.identifier.citationEryılmaz, O., Ateş, P. S., Ünal, İ., Üstündağ, Ü. V., Bay, S., Alturfan, A. A., ... Akalın, M. (2018). Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry. Journal of Biochemical and Molecular Toxicology, 32(1). https://dx.doi.org/10.1002/jbt.22015en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.22015
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2971
dc.descriptionWOS: 000419943200015en_US
dc.descriptionPubMed ID: 29283201en_US
dc.description.abstractAntimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles in daily life is an important issue for public health, still being updated. Aim was to evaluate the effects of AgNPs on the development of zebrafish embryos focusing on Wnt pathway, proliferation, oxidant-antioxidant status, and apoptosis. The expressions of ccnd1 and gsk3 beta were determined by RT-PCR, whereas beta-catenin and proliferative cell antigen (PCNA) expressions were determined immunohistochemically. Lipid peroxidation, superoxide dismutase, and glutathione-S-transferase activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Oxidant status, apoptosis, immunohistochemical PCNA, and beta-catenin staining increased, whereas ccnd1 and antioxidant enzyme activities decreased in AgNPs-exposed embryos in a dose-dependent manner. Our results indicate the interaction of possible mechanisms that may be responsible for the toxic effects of AgNPs in zebrafish embryos.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectOxidant-Antioxidant Statusen_US
dc.subjectSilver Nanoparticlesen_US
dc.subjectWnt Pathwayen_US
dc.subjectZebrafish Embryoen_US
dc.titleEvaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industryen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-0804-1475en_US
dc.authorid0000-0001-8089-1330en_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume32en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/jbt.22015en_US


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