Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry

Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2018Yazar
Eryılmaz, OğuzAteş, Perihan Seda
Ünal, İsmail
Üstündağ, Ünsal Veli
Bay, Sadık
Alturfan, Ahmet Ata
Yiğitbaşı, Türkan
Emekli Alturfan, Ebru
Akalın, Mehmet
Üst veri
Tüm öğe kaydını gösterKünye
Eryılmaz, O., Ateş, P. S., Ünal, İ., Üstündağ, Ü. V., Bay, S., Alturfan, A. A., ... Akalın, M. (2018). Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry. Journal of Biochemical and Molecular Toxicology, 32(1). https://dx.doi.org/10.1002/jbt.22015Özet
Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles in daily life is an important issue for public health, still being updated. Aim was to evaluate the effects of AgNPs on the development of zebrafish embryos focusing on Wnt pathway, proliferation, oxidant-antioxidant status, and apoptosis. The expressions of ccnd1 and gsk3 beta were determined by RT-PCR, whereas beta-catenin and proliferative cell antigen (PCNA) expressions were determined immunohistochemically. Lipid peroxidation, superoxide dismutase, and glutathione-S-transferase activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Oxidant status, apoptosis, immunohistochemical PCNA, and beta-catenin staining increased, whereas ccnd1 and antioxidant enzyme activities decreased in AgNPs-exposed embryos in a dose-dependent manner. Our results indicate the interaction of possible mechanisms that may be responsible for the toxic effects of AgNPs in zebrafish embryos.
WoS Q Kategorisi
Q2Scopus Q Kategorisi
Q3Kaynak
Journal of Biochemical and Molecular ToxicologyCilt
32Sayı
1Koleksiyonlar
- Makale Koleksiyonu [262]
- Makale Koleksiyonu [3255]
- PubMed İndeksli Yayınlar Koleksiyonu [3553]
- Scopus İndeksli Yayınlar Koleksiyonu [5461]
- WoS İndeksli Yayınlar Koleksiyonu [5651]