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dc.contributor.authorBabiloni, Claudio
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorCordone, Susanna
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorAarsland, Dag
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorCaravias, Georg
dc.contributor.authorGarn, Heinrich
dc.contributor.authorSorpresi, Fabiola
dc.contributor.authorPievani, Michela
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBasar, Erol
dc.contributor.authorYeners, Gorsev
dc.contributor.authorEmek-Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorBonanni, Laura
dc.contributor.authorDe Pandis, Maria Francesca
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:19Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:19Z
dc.date.issued2017en_US
dc.identifier.citationBabiloni, C., Del Percio, C., Lizio, R., Noce, G., Cordone, S., Lopez, S. … De Pandis, M. F. (2017). Abnormalities of cortical neural synchronization mechanisms in subjects with mild cognitive impairment due to Alzheimer's and Parkinson's diseases: An EEG study. Journal of Alzheimers Disease, 59(1), 339-358. https://dx.doi.org/10.3233/JAD-160883en_US
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.urihttps://dx.doi.org/10.3233/JAD-160883
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2948
dc.descriptionWOS: 000404876400029en_US
dc.descriptionPubMed ID: 28621693en_US
dc.description.abstractThe aim of this retrospective and exploratory study was that the cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and Parkinson's disease (PDMCI) as compared to healthy subjects. Clinical and rsEEG data of 75 ADMCI, 75 PDMCI, and 75 cognitively normal elderly (Nold) subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) was matched between the ADMCI and PDMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROC) classified these sources across individuals. Results showed that compared to the Nold group, the posterior alpha2 and alpha3 source activities were more abnormal in the ADMCI than the PDMCI group, while the parietal delta source activities were more abnormal in the PDMCI than the ADMCI group. The parietal delta and alpha sources correlated with MMSE score and correctly classified the Nold and diseased individuals (area under the ROC=0.77-0.79). In conclusion, the PDMCI and ADMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test these rsEEG markers for clinical applications and drug discovery.en_US
dc.description.sponsorshipItalian Ministry of Health [RF-2010-2319113]en_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES. The members and institutional affiliations of the Consortium are reported in the cover page of this manuscript. The activities for this study of Dr. Claudio Babiloni, Claudio Del Percio, and Roberta Lizio were performed in the framework of the project "GRIDCORE" (Italian Ministry of Health, Finalized Research program, prot. RF-2010-2319113).en_US
dc.language.isoengen_US
dc.publisherIOS Pressen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExact Low Resolution Brain Electromagnetic Source Tomographyen_US
dc.subjectMild Cognitive Impairment Due To Alzheimer's Diseaseen_US
dc.subjectReceiver Operating Characteristic Curveen_US
dc.subjectResting State Electroen-Cephalographic Rhythmsen_US
dc.titleAbnormalities of cortical neural synchronization mechanisms in subjects with mild cognitive impairment due to Alzheimer's and Parkinson's diseases: An EEG studyen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Alzheimers Diseaseen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.authorid0000-0002-0860-0524en_US
dc.identifier.volume59en_US
dc.identifier.issue1en_US
dc.identifier.startpage339en_US
dc.identifier.endpage358en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3233/JAD-160883en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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