Show simple item record

dc.contributor.authorEren, Sabri Baki
dc.contributor.authorDoğan, Remzi
dc.contributor.authorYenigün, Alper
dc.contributor.authorVeyseller, Bayram
dc.contributor.authorTuğrul, Selahattin
dc.contributor.authorÖzturan, Orhan
dc.contributor.authorAydın, Mehmet Şerif
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:47Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:47Z
dc.date.issued2017en_US
dc.identifier.citationEren, S. B., Doğan, R., Yenigün, A., Veyseller, B., Tuğrul, S., Özturan, O. ... Aydın, M. Ş. (2017). Evaluation of ototoxicity of intratympanic administration of Methotrexate in rats. International Journal of Pediatric Otorhinolaryngology, 100, 132-136. https://dx.doi.org/10.1016/j.ijporl.2017.06.035en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijporl.2017.06.035
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2813
dc.description13th International Congress of the European-Society-of-Pediatric-Otorhinolaryngology (ESPO) -- JUN 18-21, 2016 -- Lisbon, PORTUGALen_US
dc.descriptionWOS: 000409153800024en_US
dc.descriptionPubMed ID: 28802357en_US
dc.description.abstractObjective: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear. Methods: This study was planned as an animal study. This study performed in a tertiary referral center. 24 healthy female rats were used in our study. They were separated into three groups. 0.2 cc intratympanic saline was applied to both ears of Group 1. Paracentesis was applied to the tympanic membrane in both ears of Group 2. 0.2 cc intratympanic Methotrexate was applied to both ears of Group 3. At the beginning of the study, Distortion-product otoacoustic emissions (DPOAE) and Auditory brainstem response (ABR) of all rats were measured and then again on the 5th, 10th and 15th day. Histologic examinations of all groups were compared. Results: There was not any significant difference between basal DPOAE and ABR measurement values of the groups and the results were measured again on the 5th, 10th and 15th day (p > 0.05). There was no difference between the groups in terms of histology. Conclusion: The intratympanic Methotrexate injection does not have any ototoxic effect on inner ear. We assume that intratympanic Methotrexate could be used safely on inner ear diseases in which steroid treatment is contraindicated or not effective.en_US
dc.description.sponsorshipEuropean Society of Pediatric Otorhinolaryngologyen_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltd.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectOtotoxicityen_US
dc.subjectIntratympanicen_US
dc.subjectDistortion-Product Otoacoustic Emissionsen_US
dc.subjectAuditory Brainstem Responseen_US
dc.titleEvaluation of ototoxicity of intratympanic administration of Methotrexate in ratsen_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-6393-1465en_US
dc.identifier.volume100en_US
dc.identifier.startpage132en_US
dc.identifier.endpage136en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ijporl.2017.06.035en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record