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dc.contributor.authorKimyon, Günsu
dc.contributor.authorTuran, Taner
dc.contributor.authorBaşaran, Derman
dc.contributor.authorTürkmen, Osman
dc.contributor.authorKaralok, Alper
dc.contributor.authorTasçı, Tolga
dc.contributor.authorTulunay, Gökhan
dc.contributor.authorKöse, Mehmet Faruk
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:41Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:41Z
dc.date.issued2017en_US
dc.identifier.citationKimyon, G., Turan, T., Başaran, D., Türkmen, O., Karalok, A., Tasçı, T. ... Köse, M. F. (2017). Is neurosurgery with adjuvant radiotherapy an effective treatment modality in isolated brain involvement from endometrial cancer? From case report to analysis. International Journal of Gynecological Cancer, 27(2), 315-325. https://dx.doi.org/10.1097/IGC.0000000000000886en_US
dc.identifier.issn1048-891X
dc.identifier.issn1525-1438
dc.identifier.urihttps://dx.doi.org/10.1097/IGC.0000000000000886
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2785
dc.descriptionWOS: 000393415900019en_US
dc.descriptionPubMed ID: 27984379en_US
dc.description.abstractAim: The aim of this study was to evaluate the treatment options and post-brain involvement survival (PBIS) of patients with isolated brain involvement from endometrial cancer (EC). Materials and Methods: The literature electronic search was conducted from 1972 to May 2016 to identify articles about isolated (without extracranial metastases) brain involvement from EC at recurrence and the initial diagnosis. Forty-eight articles were found. After comprehensive evaluation of case series and case reports, the study included 49 cases. Results: The median age of the patients at initial diagnosis was 57 years (range, 40-77 years). Poor differentiation was determined in 36 (73.5%) patients. Thirty-five (71.4%) patients had a single brain lesion. Lesion was found in the supratentorial part of the brain in 33 (67.3%) patients. Median PBIS for all cohorts was 13 months (range, 0.25-118 months) with 2-year PBIS of 52% and 5-year PBIS of 37%. Age, tumor type, grade, disease-free interval, diagnosis time of brain lesion, localization, and number of brain lesionwere not predictive of PBIS. Two-year PBIS was 77% in patients who underwent surgical resection and radiotherapy, whereas it was 19% in the surgical resection-only group, and 20% in the primary radiotherapyYonly group (Ps = 0.003 and 0.001, respectively). Chemotherapy was not associated with improved PBIS. Conclusions: Although neuroinvasion from EC appearsmostly with a disseminated disease, there is a considerable amount of patients with isolated brain involvement who would have a higher chance of curability. Surgery with radiotherapy is the rational current management option, and this improves the survival for isolated brain involvement from EC.en_US
dc.language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIsolated Brain Recurrenceen_US
dc.subjectEndometrium Canceren_US
dc.subjectNeuroinvasionen_US
dc.subjectSurvivalen_US
dc.titleIs neurosurgery with adjuvant radiotherapy an effective treatment modality in isolated brain involvement from endometrial cancer? From case report to analysisen_US
dc.typearticleen_US
dc.relation.ispartofInternational Journal of Gynecological Canceren_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.identifier.volume27en_US
dc.identifier.issue2en_US
dc.identifier.startpage315en_US
dc.identifier.endpage325en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1097/IGC.0000000000000886en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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