dc.contributor.author | Kimyon, Günsu | |
dc.contributor.author | Turan, Taner | |
dc.contributor.author | Başaran, Derman | |
dc.contributor.author | Türkmen, Osman | |
dc.contributor.author | Karalok, Alper | |
dc.contributor.author | Tasçı, Tolga | |
dc.contributor.author | Tulunay, Gökhan | |
dc.contributor.author | Köse, Mehmet Faruk | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:41Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:41Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Kimyon, G., Turan, T., Başaran, D., Türkmen, O., Karalok, A., Tasçı, T. ... Köse, M. F. (2017). Is neurosurgery with adjuvant radiotherapy an effective treatment modality in isolated brain involvement from endometrial cancer? From case report to analysis. International Journal of Gynecological Cancer, 27(2), 315-325. https://dx.doi.org/10.1097/IGC.0000000000000886 | en_US |
dc.identifier.issn | 1048-891X | |
dc.identifier.issn | 1525-1438 | |
dc.identifier.uri | https://dx.doi.org/10.1097/IGC.0000000000000886 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2785 | |
dc.description | WOS: 000393415900019 | en_US |
dc.description | PubMed ID: 27984379 | en_US |
dc.description.abstract | Aim: The aim of this study was to evaluate the treatment options and post-brain involvement survival (PBIS) of patients with isolated brain involvement from endometrial cancer (EC). Materials and Methods: The literature electronic search was conducted from 1972 to May 2016 to identify articles about isolated (without extracranial metastases) brain involvement from EC at recurrence and the initial diagnosis. Forty-eight articles were found. After comprehensive evaluation of case series and case reports, the study included 49 cases. Results: The median age of the patients at initial diagnosis was 57 years (range, 40-77 years). Poor differentiation was determined in 36 (73.5%) patients. Thirty-five (71.4%) patients had a single brain lesion. Lesion was found in the supratentorial part of the brain in 33 (67.3%) patients. Median PBIS for all cohorts was 13 months (range, 0.25-118 months) with 2-year PBIS of 52% and 5-year PBIS of 37%. Age, tumor type, grade, disease-free interval, diagnosis time of brain lesion, localization, and number of brain lesionwere not predictive of PBIS. Two-year PBIS was 77% in patients who underwent surgical resection and radiotherapy, whereas it was 19% in the surgical resection-only group, and 20% in the primary radiotherapyYonly group (Ps = 0.003 and 0.001, respectively). Chemotherapy was not associated with improved PBIS. Conclusions: Although neuroinvasion from EC appearsmostly with a disseminated disease, there is a considerable amount of patients with isolated brain involvement who would have a higher chance of curability. Surgery with radiotherapy is the rational current management option, and this improves the survival for isolated brain involvement from EC. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Isolated Brain Recurrence | en_US |
dc.subject | Endometrium Cancer | en_US |
dc.subject | Neuroinvasion | en_US |
dc.subject | Survival | en_US |
dc.title | Is neurosurgery with adjuvant radiotherapy an effective treatment modality in isolated brain involvement from endometrial cancer? From case report to analysis | en_US |
dc.type | article | en_US |
dc.relation.ispartof | International Journal of Gynecological Cancer | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 315 | en_US |
dc.identifier.endpage | 325 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1097/IGC.0000000000000886 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |