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dc.contributor.authorTural, Deniz
dc.contributor.authorSelçukbiricik, Fatih
dc.contributor.authorYıldız, Özcan
dc.contributor.authorElçin, Olgun
dc.contributor.authorErdamar, Sibel
dc.contributor.authorGüney, Sabri
dc.contributor.authorDemireli, Fuat
dc.contributor.authorBüyükünal, Evin
dc.contributor.authorSerdengeçti, Süheyla
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:36Z
dc.date.issued2014en_US
dc.identifier.citationTural, D., Selçukbiricik, F., Yıldız, Ö., Elçin, O., Erdamar, S., Güney, S. ... Serdengeçti, S. (2014). Preoperative versus postoperative chemoradiotherapy in stage T3, N0 rectal cancer. International Journal of Clinical Oncology, 19(5), 889-896.en_US
dc.identifier.issn1341-9625
dc.identifier.issn1437-7772
dc.identifier.urihttps://dx.doi.org/10.1007/s10147-013-0636-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2759
dc.descriptionWOS: 000343887400016en_US
dc.descriptionPubMed ID: 24218281en_US
dc.description.abstractThe study populations of previous preoperative chemoradiotherapy (pre-CRT) studies have consisted of mixed clinical stages, such as cT3-cT4 and/or cN positive. For this reason, it has not been possible to demonstrate whether pre-CRT is of benefit for individual subgroups. The medical records of 137 rectal cancer patients with clinical stage T3, N0 disease who received either pre-CRT or postoperative chemoradiotherapy (post-CRT) between 2002 and 2011 were retrospectively analyzed. The regimen of pre-CRT consisted of slow fluorouracil (5FU) infusion and that of post-CRT consisted of bolus 5FU and leucovorin concurrent with radiation. Following pre-CRT, significant downstaging was achieved. However, administration of pre-CRT did not influence the type of surgical resection in tumours a parts per thousand currency sign5 cm distant from the anal verge (p = 0.14). Pathological complete response was achieved in 16 % of the patients in the pre-CRT group. The local recurrence rate (LRR) at 5 years was 5.7 % in the pre-CRT and 11.1 % in the post-CRT groups (p = 0.04). The distant recurrence rate (DRR) at 5 years was 76 % and 77 % in the pre-CRT and post-CRT groups, respectively (p = 0.1). Overall survival was similar in two groups (74.8 % vs. 75.3 %, p = 0.3). The treatment of stage T3, N0 rectal cancer patients with pre-CRT followed by surgery decreased LRR, but did not improve DRR or OS as compared with surgery followed by post-CRT in our patient cohort.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectPreoperative Chemoradiotherapyen_US
dc.subjectPostoperative Chemoradiotherapyen_US
dc.subjectStage T3 N0 Rectal Adenocarcinomaen_US
dc.subjectOutcomeen_US
dc.titlePreoperative versus postoperative chemoradiotherapy in stage T3, N0 rectal canceren_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Clinical Oncologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.startpage889en_US
dc.identifier.endpage896en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10147-013-0636-4en_US


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