dc.contributor.author | Önür, Seda Tural | |
dc.contributor.author | Sökücü, Sinem Nedime | |
dc.contributor.author | Dalar, Levent | |
dc.contributor.author | Seyhan, Ekrem Cengiz | |
dc.contributor.author | Akbaş, Ayşegül | |
dc.contributor.author | Altın, Sedat | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:25Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:25Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Önür, S. T., Sökücü, S. N., Dalar, L., Seyhan, E. C., Akbaş, A. ve Altın, S. (2015). Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy? Infectious Diseases, 47(3), 150-155. https://dx.doi.org/10.3109/00365548.2014.975278 | en_US |
dc.identifier.issn | 2374-4235 | |
dc.identifier.issn | 2374-4243 | |
dc.identifier.uri | https://dx.doi.org/10.3109/00365548.2014.975278 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2698 | |
dc.description | WOS: 000350052900006 | en_US |
dc.description | PubMed ID: 25549699 | en_US |
dc.description.abstract | Background: The differential diagnostic utilities of the levels of soluble interleukin (IL)-12p40 and the IL-2 receptor in sera and pleural effusions were evaluated in patients with exudative pleural effusions. Methods: We enrolled a total of 120 patients with exudative pleural effusions. The clinical, radiological, and histopathological diagnoses were tuberculous pleurisy in 52, malignant pleurisy in 39, and parapneumonic effusions in 29 patients. Results: We measured serum IL-12p40 and adenosine deaminase (ADA) levels in patients with tuberculous pleurisy and in a control group treated for pleural effusion to determine if such levels were useful in the diagnosis of pleural effusion (p < 0.005). Definite microbiological or histopathological diagnoses of tuberculous pleurisy or pleural effusion were recorded, and we found that ADA and serum soluble IL-2 receptor levels aided in diagnosis (p < 0.001). The levels of ADA and soluble IL-2 in pleural effusions afforded sensitivities and specificities of 84.62% and 82.69% and of 70.59% and 80.88%, respectively. The soluble IL-2 receptor level afforded a sensitivity and specificity of 82.69% and 52.9%. IL-12p40 levels in pleural effusions and sera afforded sensitivities and specifi cities of 80.77% and 80.77% and of 60.29% and 39.71%, respectively. Conclusion: Soluble IL-2 receptor levels in patients with tuberculous pleurisy serve as markers of disease in non-endemic countries, similarly to ADA levels. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | Pleural Effusion | en_US |
dc.subject | Soluble IL-2 Receptor | en_US |
dc.subject | IL-12p40 | en_US |
dc.subject | Adenosine Deaminase | en_US |
dc.title | Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy? | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Infectious Diseases | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 150 | en_US |
dc.identifier.endpage | 155 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3109/00365548.2014.975278 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |