dc.contributor.author | Hatipoğlu, İbrahim | |
dc.contributor.author | Ercan, Duygu | |
dc.contributor.author | Açılan, Ceyda | |
dc.contributor.author | Başalp, Aynur | |
dc.contributor.author | Durali, Deniz | |
dc.contributor.author | Baykal, Ahmet Tarık | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:22Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:22Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Hatipoğlu, İ., Ercan, D., Açılan, C., Başalp, A., Durali, D. ve Baykal, A. T. (2014). Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation. Immunobiology, 219(12), 944-949. https://dx.doi.org/10.1016/j.imbio.2014.07.020 | en_US |
dc.identifier.issn | 0171-2985 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.imbio.2014.07.020 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2681 | |
dc.description | WOS: 000345541900006 | en_US |
dc.description | PubMed ID: 25150150 | en_US |
dc.description.abstract | Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses during chronic infection. Hence, studying the role of HBV in immune suppression is very important for the development of alternative therapeutic strategies for HBV infections. In the present study, we investigated the effect of Hepatitis B virus e antigen (HBeAg) on the generation of bone marrow derived dendritic cells (BMDCs) and the stimulation of plasmacytoid DCs (pDCs). In the presence of HBeAg, the ratio of BMDCs was decreased, but the ratio of CD11b(+)Ly6G(+) immature myeloid cells was increased. The expression of 47 proteins was also changed during HBeAg treatment; however, CpG-induced MHC-II expression on pDCs was not affected. Our results indicate that HBeAg may have a negative effect on the generation of DCs from bone morrow precursors. (C) 2014 Elsevier GmbH. All rights reserved. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) [108S300, 110S497, 105G0656] | en_US |
dc.description.sponsorship | This study was supported by grants nos. 108S300, 110S497 and 105G0656 from The Scientific and Technological Research Council of Turkey (TUBITAK). We thank Dr. Betul Guloglu for critically reviewing the manuscript and Duygu OZCELIK for her excellent technical assistance. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Dendritic Cell | en_US |
dc.subject | HBeAg | en_US |
dc.subject | Hepatitis B Virus | en_US |
dc.subject | LC-MS/MS | en_US |
dc.subject | Proteomics | en_US |
dc.title | Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Immunobiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8814-7351 | en_US |
dc.identifier.volume | 219 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 944 | en_US |
dc.identifier.endpage | 949 | en_US |
dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/108S300 | en_US |
dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/110S497 | en_US |
dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/105G0656 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.imbio.2014.07.020 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |