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dc.contributor.authorTuncel, Deniz
dc.contributor.authorCarlos Roa, Juan
dc.contributor.authorCarlos Araya, Juan
dc.contributor.authorBellolio, Enrique
dc.contributor.authorVillaseca, Miguel
dc.contributor.authorTapia, Oscar
dc.contributor.authorJang, Kee-Taek
dc.contributor.authorQuigley, Brian
dc.contributor.authorSaka, Burcu
dc.contributor.authorBaştürk, Olca
dc.contributor.authorSarmiento, Juan
dc.contributor.authorLosada, Hector F.
dc.contributor.authorPatel, Samip
dc.contributor.authorReid, Michelle D.
dc.contributor.authorMemiş, Bahar
dc.contributor.authorAdsay, Volkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:13Z
dc.date.issued2017en_US
dc.identifier.citationTuncel, D., Carlos Roa, J., Carlos Araya, J., Bellolio, E., Villaseca, M., Tapia, O. … Adsay, V. (2017). Poorly cohesive cell (diffuse-infiltrative/signet ring cell) carcinomas of the gallbladder: Clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomas. Human Pathology, 60, 24-31. https://dx.doi.org/10.1016/j.humpath.2016.09.008en_US
dc.identifier.issn0046-8177
dc.identifier.issn1532-8392
dc.identifier.urihttps://dx.doi.org/10.1016/j.humpath.2016.09.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2626
dc.descriptionWOS: 000394069800004en_US
dc.descriptionPubMed ID: 27666767en_US
dc.description.abstractSignet ring cell carcinoma is an extremely rare type of gallbladder carcinoma: In the gastrointestinal system, carcinomas with single-cell or cord-like infiltration, previously called "diffuse-infiltrative" type or "signet ring cell," are now designated as "poorly cohesive cell" (PCC) type (regardless of with/without signet ring cells) in the World Health Organization 2010 classification. Six hundred twenty-eight primary invasive gallbladder carcinomas were reviewed for the PCC pattern. Twenty-four cases in which classical PCC pattern constituted greater than 50% of the tumor were included in the study. The mean age was 63 (range, 44-84) years. A strong female predominance was present (female/male ratio, 6.3 versus 3.9 for all gallbladder carcinomas). Most cases (79%) had advanced carcinoma (pT3+) in comparison with 51% of usual carcinomas (P < .01). All cases (100%) showed at least focal signet ring morphology (intracytoplasmic mucin), and this was predominant in 50%. Twelve cases (50%) demonstrated a focal invasive glandular component of the usual type. Overlying focal high-grade dysplasia was identified in 11 (46%). Due to block loss, immunohistochemistry could be performed in only 5 cases and revealed a profile similar to upper gastrointestinal carcinomas CK7++/CK20-+/CDX2+-/p53+. E-cadherin was decreased in the PCC component of all cases. The clinical course appeared to be more aggressive than ordinary gallbladder. carcinomas, with median survival of 3.3 months versus 11.8 months, which did not reach statistical significance (P = .06 by log-rank test). In conclusion, PCC carcinoma originating in the gallbladder should be kept in mind for the differential diagnosis of disseminated poorly differentiated carcinomas in the abdomen.en_US
dc.language.isoengen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectGallbladderen_US
dc.subjectCarcinomaen_US
dc.subjectSignet Ringen_US
dc.subjectPoorly Cohesive Cellen_US
dc.subjectDiffuse-Infiltrativeen_US
dc.titlePoorly cohesive cell (diffuse-infiltrative/signet ring cell) carcinomas of the gallbladder: Clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomasen_US
dc.typearticleen_US
dc.relation.ispartofHuman Pathologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-6830-7701en_US
dc.identifier.volume60en_US
dc.identifier.startpage24en_US
dc.identifier.endpage31en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.humpath.2016.09.008en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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