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dc.contributor.authorGüler, Ekrem
dc.contributor.authorGüler, Gamze
dc.contributor.authorKızılırmak, Filiz
dc.contributor.authorBatgerel, Ulaankhuu
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorKaraca, Oğuz
dc.contributor.authorÖzcan, Özgür
dc.contributor.authorBarutçu, İrfan
dc.contributor.authorTürkmen, Muhsin
dc.contributor.authorEsen, Ali Metin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:12Z
dc.date.issued2015en_US
dc.identifier.citationGüler, E., Güler, G., Kızılırmak, F., Batgerel, U., Demir, G. G., Güneş, H. M. ... Esen, A. M. (2015). Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome x. Herz, 40(3), 291-297. https://dx.doi.org/10.1007/s00059-014-4191-1en_US
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.urihttps://dx.doi.org/10.1007/s00059-014-4191-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2616
dc.descriptionWOS: 000362565500013en_US
dc.descriptionPubMed ID: 25676008en_US
dc.description.abstractAims. Low adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a). Patients and methods. We enrolled 53 female patients with CSX and 33 patients as the control group. The diagnosis of CSX was made according to presence of angina, findings suggestive of ischemia during stress electrocardiography or myocardial perfusion scintigraphy, and documentation of normal coronary arteries in coronary angiography. The control group consisted of patients with atypical angina and normal stress electrocardiography test results. Both groups were matched in terms of hypertension, diabetes mellitus, and metabolic syndrome. Results. Adiponectin levels were significantly decreased in patients with CSX (4.57 mu g/ml vs. 13.18 mu g/ml; p=0.001); however, Lp(a) levels were significantly increased (36.30 mg/dl vs. 7.24 mg/dl; p<0.001). Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) concentrations did not differ between the case group and the control group (p=0.14, p=0.62, p=0.64, respectively). There was no significant difference between groups in terms of age, body mass index, waist circumference hypertension, hyperlipidemia, diabetes mellitus, or metabolic syndrome. In multivariate analysis, Lp(a) and adiponectin were found to be independent predictors of CSX. An Lp(a) level of >21 mg/dl had 84% sensitivity and 96% specificity {area under the curve (AUC)=0.922, p<0.0001, 95% CI [0.842-0.970]} and an adiponectin level of <= 5.18 mu g/ml also had 58.7% sensitivity and 82.1% specificity (AUC=0.726, p=0.0003, 95% CI [ 0.609-0.823]) for detecting CSX. Conclusion. We detected low adiponectin and high Lp(a) levels in patients with CSX and these findings may be related to the microvascular injury in CSX.en_US
dc.language.isoengen_US
dc.publisherUrban & Vogelen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAdiponectinen_US
dc.subjectLipoprotein(a)en_US
dc.subjectCardiac Syndrome Xen_US
dc.subjectMicrovascular Injuryen_US
dc.subjectEtiopathogenesisen_US
dc.titleEvaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome xen_US
dc.typearticleen_US
dc.relation.journalHerzen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-4607-5724en_US
dc.authorid0000-0003-1919-3183en_US
dc.authorid0000-0001-9975-5507en_US
dc.authorid0000-0001-5825-8627en_US
dc.authorid0000-0002-4281-0867en_US
dc.identifier.volume40en_US
dc.identifier.issue3en_US
dc.identifier.startpage291en_US
dc.identifier.endpage297en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00059-014-4191-1en_US


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