dc.contributor.author | Battal, Muharrem | |
dc.contributor.author | Çitgez, Bülent | |
dc.contributor.author | Kartal, Abdülcabbar | |
dc.contributor.author | Kemik, Ahu | |
dc.contributor.author | Yıldırım, Pınar | |
dc.contributor.author | Özdenkaya, Yaşar | |
dc.contributor.author | Yılmaz, Ahmet | |
dc.contributor.author | Karatepe, Oǧuzhan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:56:11Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:56:11Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Battal, M., Çitgez, B., Kartal, A., Kemik, A., Yıldırım, P., Özdenkaya, Y. ... Karatepe, O. (2015). Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model. Hepato-Gastroenterology, 62(138), 257-260. https://dx.doi.org/10.5754/hge14958 | en_US |
dc.identifier.issn | 0172-6390 | |
dc.identifier.uri | https://dx.doi.org/10.5754/hge14958 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2611 | |
dc.description | WOS: 000352115800002 | en_US |
dc.description | PubMed ID: 25916043 | en_US |
dc.description.abstract | Background/Aims: The purpose of our study is researching into impact of glucagon like peptide 1 (GLP 1) analogue on liver regeneration after major hepatectomy. Methodology: 24 wistar albino rats were consecutively divided into 3 groups. Group 1: Control (sham) group day 14 (n=8), Group 2: Liver resection group day 14 (n=8); 70% Liver resection was performed, Group 3: Study group day 14 (n=8); Subsequent to performing 70% liver resection, GLP-1 analogue was administered 2 times a day (10 mu gr/70 kg x 2 times). After 14 day, rats were sacrificed. Oxidative stress and antioxidant enzymes and mitochondrial permeability transition, cytochrome-c, Bax, Bcl-2, caspase-3, caspase-8 and caspase-3 activity were examined. Results: 70% Liver resection induced oxidative stress of liver tissue was ameliorated by GLP 1 induction. Administration of GLP increased Bcl-2 expression. Decreased expression of cytochrome-c was accompanied by a decrease caspase-3, caspase-8, and Bax expression and caspase-3 activity. Conclusions: Glp 1 induction plays a regenerative role in the major hepatectomy. This effect is dependent on modulation of the antiapoptotic and antioxidative pathways by GLP 1 expression. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Update Medical Publishing | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | GLP-1 | en_US |
dc.subject | Liver Resection | en_US |
dc.subject | Oxidative Damage | en_US |
dc.subject | Regeneration | en_US |
dc.title | Impact of GLP-1 analogue on oxidative damage and hepatic regeneration in experimental 70% hepatectomy model | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Hepato-Gastroenterology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-0428-2511 | en_US |
dc.identifier.volume | 62 | en_US |
dc.identifier.issue | 138 | en_US |
dc.identifier.startpage | 257 | en_US |
dc.identifier.endpage | 260 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.5754/hge14958 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q2 | en_US |