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dc.contributor.authorÖztin, Hasan
dc.contributor.authorÇagıltay, Eylem
dc.contributor.authorÇağlayan, Sinan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorAkpak, Yaşam Kemal
dc.contributor.authorKaraca, Nilay
dc.contributor.authorTiğlioğlu, Mesut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:08Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:08Z
dc.date.issued2016en_US
dc.identifier.citationÖztin, H., Çagıltay, E., Çağlayan, S., Kaplan, M., Akpak, Y. K., Karaca, N. ... Tiğlioğlu, M. (2016). Kisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamic. Gynecologıcal Endocrinology, 32(12), 991-994. https://dx.doi.org/10.1080/09513590.2016.1214258en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.urihttps://dx.doi.org/10.1080/09513590.2016.1214258
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2590
dc.descriptionWOS: 000390162300014en_US
dc.descriptionPubMed ID: 27616469en_US
dc.description.abstractMale hypogonadism is defined as the deficiency of testosterone or sperm production synthesized by testicles or the deficiency of both. The reasons for hypogonadism may be primary, meaning testicular or secondary, meaning hypothalamohypophyseal. In hypogonadotropic hypogonadism (HH), there is indeficiency in gonadotropic hormones due to hypothalamic or hypophyseal reasons. Gonadotropin-releasing hormone (GnRH) is an important stimulant in releasing follicular stimulant hormone (FSH), mainly luteinizing hormone (LH). GnRH omitted is under the effect of many hormonal or stimulating factors. Kisspeptin is present in many places of the body, mostly in hypothalamic anteroventral periventricular nucleus and arcuate nucleus. Kisspeptin has a suppressor effect on the metastasis of many tumors such as breast cancer and malign melanoma metastases, and is called "metastin'' for this reason. Kisspeptin is a strong stimulant of GnRH. In idiopathic hypogonadotropic hypogonadism (IHH) etiology, there is gonadotropic hormone release indeficiency which cannot be clearly described. A total of 30 male hypogonatropic hypogonadism diagnosed patients over 30 years of age who have applied to Haydarpasa Education Hospital Endocrinology and Metabolic Diseases Service were included in the study. Compared to the control group, the effect of kisspeptin on male patients with hypogonatropic hypogonadism and on insulin resistance developing in hypogonadism patients was investigated in our study. A statistically significant difference was detected between average kisspeptin measurements of the groups (p < 0.01). Kisspeptin measurement of the cases in the patient group were detected significantly high. No statistically significant relation was detected among kisspeptin and LH/FSH levels. Although a positive low relation was detected between kisspeptin measurements of patient group cases and homeostasis model assessment of insulin resistance (HOMA-IR) measurements, this relation was statistically insignificant. When the patient and control groups were compared for HOMA-IR, no statistically significant difference was detected. The reason for high kisspeptin levels in the patient group compared to the control group makes us consider that there may be a GPR54 resistance or GnRH neuronal transfer pathway defect. When patients and control groups were compared for HOMA-IR, the difference was not statistically significant. It is considered that kisspeptin is one of the reasons for hypogonatropic hypogonadism and has less effect on insulin resistance.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlucoseen_US
dc.subjectIdiopathic Hypogonadotropic Hypogonadismen_US
dc.subjectInsulinen_US
dc.subjectInsulin Resistanceen_US
dc.subjectKisspeptinen_US
dc.titleKisspeptin levels in idiopathic hypogonadotropic hypogonadism diagnosed male patients and its relation with glucose-insulin dynamicen_US
dc.typearticleen_US
dc.relation.journalGynecologıcal Endocrinologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-3636-3853en_US
dc.identifier.volume32en_US
dc.identifier.issue12en_US
dc.identifier.startpage991en_US
dc.identifier.endpage994en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/09513590.2016.1214258en_US


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