Basit öğe kaydını göster

dc.contributor.authorYavuz Kurhan, Şule
dc.contributor.authorAkdeniz, Tuba Fatma
dc.contributor.authorHancer, Veysel Sabri
dc.contributor.authorBıçakcıgil, Müge
dc.contributor.authorCan, Meryem
dc.contributor.authorYanıkkaya Demirel, Gülderen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:05Z
dc.date.issued2016en_US
dc.identifier.citationYavuz Kurhan, Ş., Akdeniz, T. F., Hancer, V. S., Bıçakcıgil, M., Can, M. ve Yanıkkaya Demirel, G. (2016). Dual effects of testosterone in Behcet's disease: Implications for a role in disease pathogenesis. Genes And Immunity, 17(6), 335-341. https://dx.doi.org/10.1038/gene.2016.28en_US
dc.identifier.issn1466-4879
dc.identifier.issn1476-5470
dc.identifier.urihttps://dx.doi.org/10.1038/gene.2016.28
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2561
dc.descriptionWOS: 000383111500003en_US
dc.descriptionPubMed ID: 27467286en_US
dc.description.abstractBehcet's disease (BD) exhibits more severe disease course and higher mortality among male patients. However, underlying mechanisms of gender differences in clinical manifestations and disease severity are unclear. The aim of this study was to determine whether testosterone (T) has any role on BD pathogenesis. We studied peripheral blood mononuclear cells (PBMC) and neutrophils of BD patients and controls. Functional assay of neutrophils, cytokine measurements of culture supernatants and gene expressions on both cells were analyzed before and after T incubation. Neutrophils were significantly activated after incubation with T in only BD patients. Incubation with T caused significantly elevated interleukin (IL)-12 and IL-2 in BD. Gene expression of IL-10 was significantly downregulated after incubation with T in BD, especially in male patients. The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC). Toll-like receptor (TLR) 4 expression on PBMC was significantly elevated in female BD patients. ERAP1 expressions of all patients and controls were decreased under the T effect but it differed significantly between BD vs HC. Baseline IL23R expression was higher in BD males compared with females but the difference disappeared after T. When BD patients were analyzed separately, baseline C-C motif chemokine receptor1 (CCR1), STAT4, TLR4 and KLRC4 expressions were lower in males. Despite immunosuppressive behavior in healthy subjects, T causes neutrophil hyperactivation and TH1 type immune alterations in BD patients. Our results suggest that T may have a role in BD pathogenesis by altering the expression level of IL-10, TLR4, ERAP1, CCR1.en_US
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDual Effectsen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectPathogenesisen_US
dc.titleDual effects of testosterone in Behcet's disease: Implications for a role in disease pathogenesisen_US
dc.typearticleen_US
dc.relation.ispartofGenes And Immunityen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-9927-3644en_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.startpage335en_US
dc.identifier.endpage341en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1038/gene.2016.28en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ2en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster