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dc.contributor.authorAkın, Mehmet
dc.contributor.authorTurgut, Sebahat
dc.contributor.authorAyada, Ceylan
dc.contributor.authorPolat, Yusuf
dc.contributor.authorIşık Balcı, Yasemin
dc.contributor.authorErdoğan, Fırat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:04Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:04Z
dc.date.issued2011en_US
dc.identifier.citationAkın, M., Turgut, S., Ayada, C., Polat, Y., Işık Balcı, Y. ve Erdoğan, F. (2011). Relation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpura. Gene, 487(1), 80-83. https://dx.doi.org/10.1016/j.gene.2011.06.019en_US
dc.identifier.issn0378-1119
dc.identifier.urihttps://dx.doi.org/10.1016/j.gene.2011.06.019
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2559
dc.descriptionWOS: 000296823500011en_US
dc.descriptionPubMed ID: 21718764en_US
dc.description.abstractThe current study was conducted to assess 3435C>T multidrug resistance 1 gene polymorphism and the efficacy of high dose methylprednisolone (HDMP) in childhood acute idiopathic thrombocytopenic purpura patients. Methods: A total of 31 childhood acute Idiopathic thrombocytopenic purpura patients (17 females, 14 males) between the ages of 2 and 16 years of age were included in the study. High-dose methylprednisolone was given at a dose of 30 mg/kg/day for 3 days and 20 mg/kg/day for 4 days, consecutively and intravenously. Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of C3435T single nucleotide polymorphism. Fragments obtained were 238 bp to T/T genotype, 172 bp and 60 bp fragments to the C/C genotype, and 238 bp, 172 bp and 60 bp to the C/T genotype. Results: The distribution of CC, CT, and TT genotypes were 19.0%, 61.3%, and 19.4%, respectively. Both allele frequencies of C and T were the same -50%. There was no significant difference in genotype and allele distribution between the patients with LIP and the control group (chi(2)=0.84 p = 0.65, chi(2)=0.2 p = 0.63, respectively). There were no significant differences in age, gender, and pre- and post-treatment platelet counts between CC, CT, and TT genotypes of the MDR gene. Response to treatment shows no significant difference between genotype and allele groups. Conclusion: In our study, there was no difference in the HDMP treatment response between MDR1 gene genotypes. However, it should be noted that this study includes a small group of patients. Our data should therefore be considered preliminary, awaiting further confirmatory studies on an expanded patient base.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMDR1en_US
dc.subjectIdiopathic Thrombocytopenic Purpuraen_US
dc.subjectHigh Dose Methylprednisoloneen_US
dc.titleRelation between 3435C > T multidrug resistance 1 gene polymorphism with high dose methylprednisolone treatment of childhood acute idiopathic thrombocytopenic purpuraen_US
dc.typearticleen_US
dc.relation.ispartofGeneen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-6299-7067en_US
dc.identifier.volume487en_US
dc.identifier.issue1en_US
dc.identifier.startpage80en_US
dc.identifier.endpage83en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.gene.2011.06.019en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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