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dc.contributor.authorŞensoy, Özge
dc.contributor.authorAlmeida, Jose G.
dc.contributor.authorShabbir, Javeria
dc.contributor.authorMoreira, Irina S.
dc.contributor.authorMorra, Giulia
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:03Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:03Z
dc.date.issued2017en_US
dc.identifier.citationŞensoy, Ö., Almeida, J. G., Shabbir, J., Moreira, I. S. ve Morra, G. (2017). Computational studies of G protein-coupled receptor complexes: Structure and dynamics. G Protein-Coupled Receptors, 2nd Edition, Pt A içinde (205-245. ss.). https://dx.doi.org/10.1016/bs.mcb.2017.07.011en_US
dc.identifier.isbn9780128133194
dc.identifier.issn0091-679X
dc.identifier.urihttps://dx.doi.org/10.1016/bs.mcb.2017.07.011
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2547
dc.descriptionWOS: 000414418200017en_US
dc.descriptionPubMed ID: 28964337en_US
dc.description.abstractG protein-coupled receptors (GPCRs) are ubiquitously expressed transmembrane proteins associated with a wide range of diseases such as Alzheimer's, Parkinson, schizophrenia, and also implicated in in several abnormal heart conditions. As such, this family of receptors is regarded as excellent drug targets. However, due to the high number of intracellular signaling partners, these receptors have a complex interaction networks and it becomes challenging to modulate their function. Experimentally determined structures give detailed information on the salient structural properties of these signaling complexes but they are far away from providing mechanistic insights into the underlying process. This chapter presents some of the computational tools, namely molecular dynamics, molecular docking, and molecular modeling and related analyses methods that have been used to complement experimental findings.en_US
dc.language.isoengen_US
dc.publisherElsevier Academic Press Incen_US
dc.relation.ispartofseriesMethods in Cell Biology
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStructure and Dynamicsen_US
dc.subjectG Proteinen_US
dc.subjectReceptor Complexesen_US
dc.titleComputational studies of G protein-coupled receptor complexes: Structure and dynamicsen_US
dc.typebookParten_US
dc.relation.ispartofG Protein-Coupled Receptors, 2nd Edition, Pt Aen_US
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.authorid0000-0001-5950-3436en_US
dc.identifier.volume142en_US
dc.identifier.startpage205en_US
dc.identifier.endpage245en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.identifier.doi10.1016/bs.mcb.2017.07.011en_US
dc.identifier.wosqualityQ4en_US


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