dc.contributor.author | Çelik, Önder | |
dc.contributor.author | Erşahin, Aynur | |
dc.contributor.author | Acet, Mustafa | |
dc.contributor.author | Çelik, Nilüfer | |
dc.contributor.author | Baykuş, Yakup | |
dc.contributor.author | Deniz, Rulin | |
dc.contributor.author | Özerol, Elif | |
dc.contributor.author | Özerol, İbrahim | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:55:57Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:55:57Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Çelik, Ö., Erşahin, A., Acet, M., Çelik, N., Baykuş, Y., Deniz, R. ... Özerol, İ. (2016). Disulfiram, as a candidate NF-kappa B and proteasome inhibitor, prevents endometriotic implant growing in a rat model of endometriosis. European Review For Medical and Pharmacological Sciences, 20(20), 4380-4389. | en_US |
dc.identifier.issn | 1128-3602 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2492 | |
dc.description | WOS: 000388238500028 | en_US |
dc.description | PubMed ID: 27831632 | en_US |
dc.description.abstract | OBJECTIVE: Disulfiram (DSF) exerts its therapeutic effects through oxidative, proteasome, and nuclear factor kappa beta (NF-kappa B) pathways. The study was planned to test the impact of DSF on growing of endometriotic implants in rats with experimentally induced endometriosis. PATIENTS AND METHODS: Thirty rats were labeled as the control (n = 8), sham (n = 6), GnRH-agonist (n = 8) and the DSF (n = 8) groups. The rats in the group 3 exposed to single dose leuprolide acetate. The rats in group 4 were treated with DSF for 21 days. The serum activity of oxidant and antioxidant markers, total oxidant status (TOS), total antioxidant status (TAS), interleukin-1 beta, and tumor necrosis factora (TNF-alpha) were determined. Implants were processed for NF-kappa B, PCNA, and CD34 immunostaining. RESULTS: The serum concentration of malondialdehyde in the DSF group was significantly higher than those in other groups. The concentration of TAS, TNF-alpha, and interleukin-1 beta in the DSF group considerably decreased compared to control group. Following treatment with DSF while the percentage of Grade 1 and 2 implants increased the percentage of Grade 3 and 4 implants decreased. The implants disappeared totally in two cases in the DSF group and one case in the GnRH-agonist group. The mean H-Scores of implant NF-kappa B and PCNA in DSF treated animals were found to significantly lower than those of the control group. CONCLUSIONS: By decreasing NF-kappa B expression, angiogenesis, and cell proliferation DSF prevents the growth of endometriotic implants. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Verduci Publisher | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Endometriosis | en_US |
dc.subject | Disulfiram | en_US |
dc.subject | NF-Kappa B | en_US |
dc.subject | Oxidative Stress | en_US |
dc.title | Disulfiram, as a candidate NF-kappa B and proteasome inhibitor, prevents endometriotic implant growing in a rat model of endometriosis | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Review For Medical and Pharmacological Sciences | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 20 | en_US |
dc.identifier.startpage | 4380 | en_US |
dc.identifier.endpage | 4389 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |