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dc.contributor.authorArslan, Ferhat
dc.contributor.authorMeynet, Elodie
dc.contributor.authorSünbül, Mustafa
dc.contributor.authorSipahi, Oğuz Reşat
dc.contributor.authorKurtaran, Behice
dc.contributor.authorKaya, Selçuk
dc.contributor.authorİnkaya, Ahmet
dc.contributor.authorPagliano, Pasquale
dc.contributor.authorŞengöz, Gönül
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorKayaaslan, Bircan
dc.contributor.authorYıldız, Orhan
dc.contributor.authorGüven, Tümer
dc.contributor.authorTürker, Nesrin
dc.contributor.authorMidi, İpek
dc.contributor.authorParlak, Emine
dc.contributor.authorTosun, Selma
dc.contributor.authorErol, Serpil
dc.contributor.authorİnan, Asuman
dc.contributor.authorÖztoprak, Nefise
dc.contributor.authorBalkan, İlker
dc.contributor.authorAksoy, Y.
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorMert, Ali
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:27Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:27Z
dc.date.issued2015en_US
dc.identifier.citationArslan, F., Meynet, E., Sünbül, M., Sipahi, O. R., Kurtaran, B., Kaya, S. ... Mert, A. (2015). The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: A multinational study. European Journal of Clinical Microbiology and Infectious Diseases, 34(6), 1213-1221. https://dx.doi.org/10.1007/s10096-015-2346-5en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.urihttps://dx.doi.org/10.1007/s10096-015-2346-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2404
dc.descriptionWOS: 000354195100020en_US
dc.descriptionPubMed ID: 25698311en_US
dc.description.abstractThe aim of this study was to determine the independent risk factors, morbidity, and mortality of central nervous system (CNS) infections caused by Listeria monocytogenes. We retrospectively evaluated 100 episodes of neuroinvasive listeriosis in a multinational study in 21 tertiary care hospitals of Turkey, France, and Italy from 1990 to 2014. The mean age of the patients was 57 years (range, 19-92 years), and 64% were males. The all-cause immunosuppression rate was 54 % (54/100). Forty-nine (49 %) patients were referred to a hospital because of the classical triad of symptoms (fever, nuchal rigidity, and altered level of consciousness). Rhombencephalitis was detected radiologically in 9 (9 %) cases. Twenty-seven (64 %) of the patients who had cranial magnetic resonance imaging (MRI) performed had findings of meningeal and parenchymal involvement. The mean delay in the initiation of specific treatment was 6.8 +/- 7 days. Empiric treatment was appropriate in 52 (52 %) patients. The mortality rate was 25 %, while neurologic sequelae occurred in 13 % of the patients. In the multivariate analysis, delay in treatment [odds ratio (OR), 1.07 [95 % confidence interval (CI), 1.01-1.16]] and seizures (OR, 3.41 [95 % CI, 1.05-11.09]) were significantly associated with mortality. Independent risk factors for neurologic sequelae were delay in treatment (OR, 1.07 [95 % CI, 1.006-1.367]) and presence of bacteremia (OR, 45.2 [95 % CI, 2.73-748.1]). Delay in the initiation of treatment of neuroinvasive listeriosis was a poor risk factor for unfavorable outcomes. Bacteremia was one of the independent risk factors for morbidity, while the presence of seizures predicted worse prognosis. Moreover, the addition of aminoglycosides to ampicillin monotherapy did not improve patients' prognosis.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectClinical Featuresen_US
dc.subjectDiagnosisen_US
dc.subjectTreatmenten_US
dc.subjectPrognosisen_US
dc.subjectNeuroinvasive Listeriosisen_US
dc.titleThe clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: A multinational studyen_US
dc.typearticleen_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology and Infectious Diseasesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-8554-7651en_US
dc.authorid0000-0001-9658-7560en_US
dc.authorid0000-0001-8022-7325en_US
dc.authorid0000-0001-8945-2385en_US
dc.identifier.volume34en_US
dc.identifier.issue6en_US
dc.identifier.startpage1213en_US
dc.identifier.endpage1221en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10096-015-2346-5en_US
dc.identifier.wosqualityQ3en_US
dc.identifier.scopusqualityQ1en_US


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