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dc.contributor.authorCevizci, Raşit
dc.contributor.authorDüzlü, Mehmet
dc.contributor.authorDündar, Yasemin
dc.contributor.authorNoyanalpan, Ningur
dc.contributor.authorSultan, Nedim
dc.contributor.authorTutar, Hakan
dc.contributor.authorBayazıt, Yıldırım Ahmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:18Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:18Z
dc.date.issued2015en_US
dc.identifier.citationCevizci, R., Düzlü, M., Dündar, Y., Noyanalpan, N., Sultan, N., Tutar, H. ve Bayazıt, Y. A. (2015). Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation. European Archives of Oto-Rhino-Laryngology, 272(6), 1389-1393. https://dx.doi.org/10.1007/s00405-014-2942-5en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-014-2942-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2379
dc.descriptionWOS: 000354623800009en_US
dc.descriptionPubMed ID: 24570174en_US
dc.description.abstractThe purpose of the study is to assess the effect of a novel quorum sensing inhibitor (QSI), coded as 'yd 47', against otitis media and biofilm formation on Cochlear implants (CIs). Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs. The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline, respectively. The right and left middle ears were also instilled with a solution containing pneumococci and saline, respectively. The animals were only given an intraperitoneal 'yd 47' twice daily for three months to be assessed later with electron microscopy. Clinical examination with palpation, inspection and otoscopy did not reveal any sign of implant infection or otitis media. In the study and control implant materials, soft tissues around the implant and tympanic membranes, there was no biofilm formation by pneumococci. Contamination by various cells and some rod-shaped bacteria (not diplococcic) were seen in some of the materials. In conclusion, the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci.en_US
dc.description.sponsorshipMEDers(R) companyen_US
dc.description.sponsorshipThis study was supported financialy by MEDers (R) company (Authorized Distrubutor of MED-EL (R) company in Turkey). I (we) certifiy that we don't have any interest in this company.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBiofilmen_US
dc.subjectQuorum Sensingen_US
dc.subjectCochlear Implant Infectionen_US
dc.titlePreliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantationen_US
dc.typearticleen_US
dc.relation.journalEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-3887-4569en_US
dc.identifier.volume272en_US
dc.identifier.issue6en_US
dc.identifier.startpage1389en_US
dc.identifier.endpage1393en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00405-014-2942-5en_US


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