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dc.contributor.authorKonak, Murat
dc.contributor.authorCıncık, Hakan
dc.contributor.authorErkul, Evren
dc.contributor.authorKüçükodacı, Zafer
dc.contributor.authorGüngör, Atila
dc.contributor.authorÖzdemir, Sevim
dc.contributor.authorÇekin, Engin
dc.contributor.authorArisan, Volkan
dc.contributor.authorMutluoğlu, Mesut
dc.contributor.authorSalihoğlu, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:17Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:17Z
dc.date.issued2016en_US
dc.identifier.citationKonak, M., Cıncık, H., Erkul, E., Küçükodacı, Z., Güngör, A., Özdemir, S. ... Salihoğlu, M. (2016). The protective effects of different treatments on rat salivary glands after radiotherapy. European Archives Of Oto-Rhino-Laryngology, 273(12), 4501-4506. https://dx.doi.org/10.1007/s00405-016-4159-2en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-016-4159-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2375
dc.descriptionWOS: 000387700400056en_US
dc.descriptionPubMed ID: 27324888en_US
dc.description.abstractThis study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectSalivary Glandsen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectCorticosteroiden_US
dc.titleThe protective effects of different treatments on rat salivary glands after radiotherapyen_US
dc.typearticleen_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume273en_US
dc.identifier.issue12en_US
dc.identifier.startpage4501en_US
dc.identifier.endpage4506en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00405-016-4159-2en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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