dc.contributor.author | Marchetto, Maria Carolina | |
dc.contributor.author | Hrvoj-Mihic, Branka | |
dc.contributor.author | Kerman, Bilal Ersen | |
dc.contributor.author | Yu, Diana X. | |
dc.contributor.author | Vadodaria, Krishna C. | |
dc.contributor.author | Linker, Sara B. | |
dc.contributor.author | Narvaiza, Inigo | |
dc.contributor.author | Santos, Renata | |
dc.contributor.author | Denli, Ahmet M. | |
dc.contributor.author | Mendes, Ana P. D. | |
dc.contributor.author | Oefner, Ruth | |
dc.contributor.author | Cook, Jonathan | |
dc.contributor.author | McHenry, Lauren | |
dc.contributor.author | Grasmick, Jaeson M. | |
dc.contributor.author | Heard, Kelly | |
dc.contributor.author | Fredlender, Callie | |
dc.contributor.author | Randolph-Moore, Lynne | |
dc.contributor.author | Kshirsagar, Rijul | |
dc.contributor.author | Xenitopoulos, Rea | |
dc.contributor.author | Chou, Grace | |
dc.contributor.author | Hah, Nasun | |
dc.contributor.author | Muotri, Alysson R. | |
dc.contributor.author | Padmanabhan, Krishnan | |
dc.contributor.author | Semendeferi, Katerina | |
dc.contributor.author | Gage, Fred H. | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:52:00Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:52:00Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Marchetto, M. C., Hrvoj-Mihic, B., Kerman, B., Yu, D., Vadodaria, K., Linker, S. ... Gage, F. (2019). Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Journal of Elife, 8. https://dx.doi.org/10.7554/eLife.37527 | en_US |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | https://dx.doi.org/10.7554/eLife.37527 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2324 | |
dc.description | WOS: 000458101700001 | en_US |
dc.description | PubMed ID: 30730291 | en_US |
dc.description.abstract | Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex. Our results show differential migration patterns in human neural progenitor cells compared to those of chimpanzees and bonobos both in vitro and in vivo, suggesting heterochronic changes in human neurons. The strategy proposed here lays the groundwork for further comparative analyses between humans and NHPs and opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species. | en_US |
dc.description.sponsorship | National Institutes of Health; California Institute for Regenerative Medicine; National Alliance for Research on Schizophrenia and Depression; Leona M. and Harry B. Helmsley Charitable Trust; Salk Cancer Center [NCI P30 CA014195] | en_US |
dc.description.sponsorship | National Institutes of Health Research Project Grant Maria C Marchetto Alysson R Muotri Krishnan Padmanabhan Fred H Gage; California Institute for Regenerative Medicine Research Grant Alysson R Muotri; National Institutes of Health Pathway to independence award Krishnan Padmanabhan; National Alliance for Research on Schizophrenia and Depression Young Investigator award Krishnan Padmanabhan; Leona M. and Harry B. Helmsley Charitable Trust Research Project Grant Fred H Gage Salk Cancer Center NCI P30 CA014195 Fred H Gage; The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elife Sciences Publications Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Species-Specific | en_US |
dc.subject | Cells | en_US |
dc.subject | Human | en_US |
dc.subject | Neural | en_US |
dc.title | Species-specific maturation profiles of human, chimpanzee and bonobo neural cells | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Elife | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.authorid | 0000-0003-1106-3288 | en_US |
dc.identifier.volume | 8 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.7554/eLife.37527 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |