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dc.contributor.authorMarchetto, Maria Carolina
dc.contributor.authorHrvoj-Mihic, Branka
dc.contributor.authorKerman, Bilal Ersen
dc.contributor.authorYu, Diana X.
dc.contributor.authorVadodaria, Krishna C.
dc.contributor.authorLinker, Sara B.
dc.contributor.authorNarvaiza, Inigo
dc.contributor.authorSantos, Renata
dc.contributor.authorDenli, Ahmet M.
dc.contributor.authorMendes, Ana P. D.
dc.contributor.authorOefner, Ruth
dc.contributor.authorCook, Jonathan
dc.contributor.authorMcHenry, Lauren
dc.contributor.authorGrasmick, Jaeson M.
dc.contributor.authorHeard, Kelly
dc.contributor.authorFredlender, Callie
dc.contributor.authorRandolph-Moore, Lynne
dc.contributor.authorKshirsagar, Rijul
dc.contributor.authorXenitopoulos, Rea
dc.contributor.authorChou, Grace
dc.contributor.authorHah, Nasun
dc.contributor.authorMuotri, Alysson R.
dc.contributor.authorPadmanabhan, Krishnan
dc.contributor.authorSemendeferi, Katerina
dc.contributor.authorGage, Fred H.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:00Z
dc.date.issued2019en_US
dc.identifier.citationMarchetto, M. C., Hrvoj-Mihic, B., Kerman, B., Yu, D., Vadodaria, K., Linker, S. ... Gage, F. (2019). Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Journal of Elife, 8. https://dx.doi.org/10.7554/eLife.37527en_US
dc.identifier.issn2050-084X
dc.identifier.urihttps://dx.doi.org/10.7554/eLife.37527
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2324
dc.descriptionWOS: 000458101700001en_US
dc.descriptionPubMed ID: 30730291en_US
dc.description.abstractComparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex. Our results show differential migration patterns in human neural progenitor cells compared to those of chimpanzees and bonobos both in vitro and in vivo, suggesting heterochronic changes in human neurons. The strategy proposed here lays the groundwork for further comparative analyses between humans and NHPs and opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species.en_US
dc.description.sponsorshipNational Institutes of Health; California Institute for Regenerative Medicine; National Alliance for Research on Schizophrenia and Depression; Leona M. and Harry B. Helmsley Charitable Trust; Salk Cancer Center [NCI P30 CA014195]en_US
dc.description.sponsorshipNational Institutes of Health Research Project Grant Maria C Marchetto Alysson R Muotri Krishnan Padmanabhan Fred H Gage; California Institute for Regenerative Medicine Research Grant Alysson R Muotri; National Institutes of Health Pathway to independence award Krishnan Padmanabhan; National Alliance for Research on Schizophrenia and Depression Young Investigator award Krishnan Padmanabhan; Leona M. and Harry B. Helmsley Charitable Trust Research Project Grant Fred H Gage Salk Cancer Center NCI P30 CA014195 Fred H Gage; The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.en_US
dc.language.isoengen_US
dc.publisherElife Sciences Publications Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSpecies-Specificen_US
dc.subjectCellsen_US
dc.subjectHumanen_US
dc.subjectNeuralen_US
dc.titleSpecies-specific maturation profiles of human, chimpanzee and bonobo neural cellsen_US
dc.typearticleen_US
dc.relation.ispartofElifeen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-1106-3288en_US
dc.identifier.volume8en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.7554/eLife.37527en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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