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dc.contributor.authorKahraman, Aysu
dc.contributor.authorSeyhan, Kübra
dc.contributor.authorDeğer, Ünal
dc.contributor.authorKutlutürk, Seval
dc.contributor.authorMutlu, Akmer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:49Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:49Z
dc.date.issued2016en_US
dc.identifier.citationKahraman, A., Seyhan, K., Değer, Ü., Kutlutürk, S. ve Mutlu, A. (2016). Should botulinum toxin a injections be repeated in children with cerebral palsy? A systematic review. Developmental Medicine And Child Neurology, 58(9), 910-917. https://dx.doi.org/10.1111/dmcn.13135en_US
dc.identifier.issn0012-1622
dc.identifier.issn1469-8749
dc.identifier.urihttps://dx.doi.org/10.1111/dmcn.13135
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2290
dc.descriptionWOS: 000382852000011en_US
dc.descriptionPubMed ID: 27103334en_US
dc.description.abstractAimThe aim of this study was to determine the effects of repeat botulinum toxin A (BoNT-A) injections in children with spastic cerebral palsy (CP) on the basis of a best evidence synthesis. MethodThis study included 13 original articles after searching the literature to retrieve information. We used the critical review form produced by McMaster University to determine the methodological quality of the studies, and then confirmed the levels of evidence from Sackett. The studies were also evaluated using the International Classification of Function, Disability and Health - Children and Youth Version (ICF-CY). ResultsA total of 893 children with spastic CP who had been administered repeat BoNT-A injections were evaluated. The evidence level was II in four of the thirteen studies, III in four studies, and IV in five studies. The McMaster review form score was 14 in two studies, 13 in four studies, and 12 in seven studies. The results showed that repeat BoNT-A may be a safe and an effective approach. The first two injections/one repeat especially relieve spasticity and improve fine and gross motor activities. InterpretationFuture studies to investigate the effectiveness of repeat BoNT-A in children with spastic CP may be planned within the framework of the ICF-CY to include well-designed randomized controlled trials and those conducted on larger homogenous groups.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBotulinum Toxinen_US
dc.subjectChildren With Cerebral Palsyen_US
dc.subjectRepeateden_US
dc.titleShould botulinum toxin a injections be repeated in children with cerebral palsy? A systematic reviewen_US
dc.typereviewen_US
dc.relation.journalDevelopmental Medicine And Child Neurologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümüen_US
dc.identifier.volume58en_US
dc.identifier.issue9en_US
dc.identifier.startpage910en_US
dc.identifier.endpage917en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1111/dmcn.13135en_US


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