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dc.contributor.authorYuluğ, Burak
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorAltunay, Serdar
dc.contributor.authorErsavaş, Cenk
dc.contributor.authorOrhan, Cemal
dc.contributor.authorDalay, Arman
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorJuturu, Vijaya
dc.contributor.authorŞahin, Kazım
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:30Z
dc.date.issued2018en_US
dc.identifier.citationYuluğ, B., Kılıç, E., Altunay, S., Ersavaş, C., Orhan, C., Dalay, A. ... Şahin, K. (2018). Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice. Journal of Cns & Neurological Disorders-Drug Targets, 17(6), 439-447. https://dx.doi.org/10.2174/1871527317666180501110918en_US
dc.identifier.issn1871-5273
dc.identifier.issn1996-3181
dc.identifier.urihttps://dx.doi.org/10.2174/1871527317666180501110918
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2227
dc.descriptionWOS: 000441417400005en_US
dc.descriptionPubMed ID: 29714150en_US
dc.description.abstractIntroduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. Despite many preclinical studies showing the anti-oxidative and anti-inflammatory effects of cinnamon, the underlying mechanisms in signaling pathways via which cinnamon protects the brain after brain trauma remained largely unknown. However, there is still no preclinical study delineating the possible molecular mechanism of neuroprotective effects cinnamon polyphenol extract in Traumatic Brain Injury (TBI). The primary aim of the current study was to test the hypothesis that cinnamon polyphenol extract administration would improve the histopathological outcomes and exert neuroprotective activity through its antioxidative and anti-inflammatory properties following TBI. Methods: To investigate the effects of cinnamon, we induced brain injury using a cold trauma model in male mice that were treated with cinnamon polyphenol extract (10 mg/kg) or vehicle via intraperitoneal administration just after TBI. Mice were divided into two groups: TBI+vehicle group and TBI+ cinnamon polyphenol extract group. Brain samples were collected 24 h later for analysis. Results: We have shown that cinnamon polyphenol extract effectively reduced infarct and edema formation which were associated with significant alterations in inflammatory and oxidative parameters, including nuclear factor-KB, interleukin 1-beta, interleukin 6, nuclear factor erythroid 2-related factor 2, glial fibrillary acidic protein, neural cell adhesion molecule, malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase. Conclusion: Our results identify an important neuroprotective role of cinnamon polyphenol extract in TBI which is mediated by its capability to suppress the inflammation and oxidative injury. Further, specially designed experimental studies to understand the molecular cross-talk between signaling pathways would provide valuable evidence for the therapeutic role of cinnamon in TBI and other TBI related conditions.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publishers Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCinnamonen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectGlial Fibrillary Acidic Proteinen_US
dc.subjectInterleukin 1-Betaen_US
dc.subjectInterleukin 6en_US
dc.subjectNeural Cell Adhesion Moleculeen_US
dc.subjectNuclear Factor-Kappa Ben_US
dc.subjectNuclear Factor Erythroid 2-Related Factor 2en_US
dc.subjectMalondialdehydeen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.titleCinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male miceen_US
dc.typearticleen_US
dc.relation.ispartofCns & Neurological Disorders-Drug Targetsen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-9704-6173en_US
dc.authorid0000-0001-6494-8923en_US
dc.authorid0000-0002-4051-2559en_US
dc.authorid0000-0001-5134-1014en_US
dc.authorid0000-0002-9013-2298en_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.startpage439en_US
dc.identifier.endpage447en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871527317666180501110918en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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