dc.contributor.author | Seyhan, Ekrem | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:51:07Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:51:07Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Seyhan, E. (2015). Diagnosing Latent Tuberculosis in Immunocompromised Patients Measuring Blood IP-10 Production Capacity: An Analysis of Chronic Renal Failure Patients. Chest, 148(4). https://dx.doi.org/10.1378/chest.2278323 | en_US |
dc.identifier.issn | 0012-3692 | |
dc.identifier.uri | https://dx.doi.org/10.1378/chest.2278323 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2151 | |
dc.description | WOS: 000366134400111 | en_US |
dc.description.abstract | PURPOSE: Patients undergoing haemodialysis for chronic renal failure (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. METHODS: The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using Quantiferon G-In-Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. RESULTS: TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (κ=1). CONCLUSIONS: Blood IP-10 level, which can be measured simply, provides results equivalent to interferon-γ release assays for the diagnosis of LTBI in CRF-HD patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American College of Chest Physicians | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Diagnosing | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | Measuring Blood | en_US |
dc.title | Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients | en_US |
dc.type | conferenceObject | en_US |
dc.relation.ispartof | Chest | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6639-2797 | en_US |
dc.identifier.volume | 148 | en_US |
dc.identifier.issue | 4 | en_US |
dc.relation.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1378/chest.2278323 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |