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dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorÇelik, Önder
dc.contributor.authorAydın, Süleyman
dc.contributor.authorÖzercan, Hanifi
dc.contributor.authorAcet, Mustafa
dc.contributor.authorAydın, Yalçın
dc.contributor.authorArtaş, Gökhan
dc.contributor.authorTürk, Ahmet
dc.contributor.authorYardım, Meltem
dc.contributor.authorOzan, Gonca
dc.contributor.authorYalçın, Mehmet Hanifi
dc.contributor.authorKocaman, Nevin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:05Z
dc.date.issued2016en_US
dc.identifier.citationKuloğlu, T., Çelik, Ö., Aydın, S., Özercan, H., Acet, M., Aydın, Y. ... Kocaman, N. (2016). Irisin immunostaining characteristics of breast and ovarian cancer cells. Cellular And Molecular Biology, 62(8), 40-44. https://dx.doi.org/10.14715/cmb/2016.62.8.7en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.urihttps://dx.doi.org/10.14715/cmb/2016.62.8.7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2142
dc.descriptionWOS: 000386769600007en_US
dc.descriptionPubMed ID: 27545213en_US
dc.description.abstractTo determine expression pattern of irisin in tissues obtained from human ovarian cancer, breast cancer, and cervix cancer. Tissue samples obtained from subjects with breast cancer, ovarian cancer cervix cancer, simple endometrial hyperplasia, complex atypical endometrial hyperplasia. At least five sections from each subject were immunohistochemically stained with irisin antibody, and H-score method was used to evaluate irisin intensity. Tissues obtained from healthy breast tissues, proliferative phase endometrium adenomyosis and benign ovarian tumors were accepted as control. Irisin activity was not detected in control breast tissues significantly increased irisin staining was detected in invasive lobular, intraductal papillary, invasive ductal, invasive papillary, and mucinous carcinomas compared to control tissues. Also, significantly increased irisin immunoreactivity was detected in both ovarian endometriosis and mucinous carcinomas compared to benign tumors. However irisin staining was not observed at the papillary carcinoma of the ovary while sections obtained from simple and complex atypical endometrial hyperplasia, and cervix carcinoma demonstrated irisin immunoreactivity. Increased irisin immunoreactivity in tissues obtained from breast, ovary, cervix carcinomas, and endometrial hyperplasia suggest critical role of this peptide during carcinogenesis.en_US
dc.language.isoengen_US
dc.publisherC M B Assocen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIrisinen_US
dc.subjectBreast Canceren_US
dc.subjectOvarian Canceren_US
dc.subjectCervix Canceren_US
dc.subjectEndometrial Hyperplasiaen_US
dc.titleIrisin immunostaining characteristics of breast and ovarian cancer cellsen_US
dc.typearticleen_US
dc.relation.journalCellular And Molecular Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.identifier.volume62en_US
dc.identifier.issue8en_US
dc.identifier.startpage40en_US
dc.identifier.endpage44en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.14715/cmb/2016.62.8.7en_US


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