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dc.contributor.authorKızılırmak, Filiz
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorDemir, Gültekin Günhan
dc.contributor.authorGökdeniz, Tayyar
dc.contributor.authorGüler, Ekrem
dc.contributor.authorÇakal, Beytullah
dc.contributor.authorOmaygenç, Mehmet Onur
dc.contributor.authorYılmaz, Fatih
dc.contributor.authorSavur, Ümeyir
dc.contributor.authorBarutçu, İrfan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:00Z
dc.date.issued2015
dc.identifier.citationKızılırmak, F., Güneş, H. M., Demir, G. G., Gökdeniz, T., Gökdeniz, T., Güler, E. ... Barutçu, İ. (2015). Impact of intracoronary adenosine on myonecrosis in patients with unstable angina pectoris undergoing percutaneous coronary intervention. Cardiovascular Drugs and Therapy, 29(6), 519-526. https://dx.doi.org/10.1007/s10557-015-6631-4en_US
dc.identifier.issn0920-3206
dc.identifier.issn1573-7241
dc.identifier.urihttps://dx.doi.org/10.1007/s10557-015-6631-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2124
dc.descriptionWOS: 000368454100003en_US
dc.descriptionPubMed ID: 26631392en_US
dc.description.abstractBackground In this study, we aimed to investigate the impact of prophylactic intracoronary adenosine administered during percutaneous coronary intervention (PCI) due to unstable angina pectoris on myonecrosis by measuring post-procedural levels of cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB). Methods A total of 122 patients with unstable angina undergoing PCI were included in this single-center, double-blind, randomized study. The patients were randomly allocated to adenosine and placebo groups. In the adenosine group, a single-dose of intracoronary adenosine (100 mu g for the right coronary artery and 150 mu g for the left coronary artery) was administered. Primary endpoint was post-PCI myonecrosis, which was defined as abnormal levels of periprocedural cTnI. Secondary endpoints were defined as elevated cTnI levels [5 x upper limit of normal (ULN)], abnormal CK-MB levels, angiographic coronary flow measured by Thrombolysis In Myocardial Infarction (TIMI) frame count (TFC), the cumulative incidence of in-hospital death and in-hospital urgent target vessel revascularization (TVR). Results Clinical and angiographic characteristics of both adenosine (61 patients, 61 +/- 9 years) and placebo (61 patients, 59 +/- 10 years) groups were similar (p > 0.05 for all). Post-procedural abnormal cTnI levels in the adenosine group were significantly lower than the placebo group (32 % vs. 55 %, p: 0.011). cTnI > 5 x ULN (21 % vs. 31 %, p: 0.217) and abnormal CK-MB levels (11 % vs. 19 %, p: 0.263) were similar in both groups. Post-procedural TFCs in the adenosine group were significantly lower than the placebo group (24 +/- 4 vs. 27 +/- 5, p: 0.004). In-hospital events including death and urgent TVR were not observed in either group. Conclusion Intracoronary administration of single-dose adenosine in patients with unstable angina undergoing PCI is associated with decreased periprocedural myonecrosis and improved coronary blood flow.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectMyonecrosisen_US
dc.subjectAdenosineen_US
dc.subjectPercutaneous Coronary Interventionen_US
dc.subjectUnstable Anginaen_US
dc.titleImpact of intracoronary adenosine on myonecrosis in patients with unstable angina pectoris undergoing percutaneous coronary interventionen_US
dc.typearticleen_US
dc.relation.journalCardiovascular Drugs and Therapyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-1919-3183en_US
dc.authorid0000-0001-9975-5507en_US
dc.authorid0000-0002-4607-5724en_US
dc.authorid0000-0003-0230-6575en_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.startpage519en_US
dc.identifier.endpage526en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10557-015-6631-4en_US


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