dc.contributor.author | Kızılırmak, Filiz | |
dc.contributor.author | Güneş, Hacı Murat | |
dc.contributor.author | Demir, Gültekin Günhan | |
dc.contributor.author | Gökdeniz, Tayyar | |
dc.contributor.author | Güler, Ekrem | |
dc.contributor.author | Çakal, Beytullah | |
dc.contributor.author | Omaygenç, Mehmet Onur | |
dc.contributor.author | Yılmaz, Fatih | |
dc.contributor.author | Savur, Ümeyir | |
dc.contributor.author | Barutçu, İrfan | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:51:00Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:51:00Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Kızılırmak, F., Güneş, H. M., Demir, G. G., Gökdeniz, T., Gökdeniz, T., Güler, E. ... Barutçu, İ. (2015). Impact of intracoronary adenosine on myonecrosis in patients with unstable angina pectoris undergoing percutaneous coronary intervention. Cardiovascular Drugs and Therapy, 29(6), 519-526. https://dx.doi.org/10.1007/s10557-015-6631-4 | en_US |
dc.identifier.issn | 0920-3206 | |
dc.identifier.issn | 1573-7241 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s10557-015-6631-4 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2124 | |
dc.description | WOS: 000368454100003 | en_US |
dc.description | PubMed ID: 26631392 | en_US |
dc.description.abstract | Background In this study, we aimed to investigate the impact of prophylactic intracoronary adenosine administered during percutaneous coronary intervention (PCI) due to unstable angina pectoris on myonecrosis by measuring post-procedural levels of cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB). Methods A total of 122 patients with unstable angina undergoing PCI were included in this single-center, double-blind, randomized study. The patients were randomly allocated to adenosine and placebo groups. In the adenosine group, a single-dose of intracoronary adenosine (100 mu g for the right coronary artery and 150 mu g for the left coronary artery) was administered. Primary endpoint was post-PCI myonecrosis, which was defined as abnormal levels of periprocedural cTnI. Secondary endpoints were defined as elevated cTnI levels [5 x upper limit of normal (ULN)], abnormal CK-MB levels, angiographic coronary flow measured by Thrombolysis In Myocardial Infarction (TIMI) frame count (TFC), the cumulative incidence of in-hospital death and in-hospital urgent target vessel revascularization (TVR). Results Clinical and angiographic characteristics of both adenosine (61 patients, 61 +/- 9 years) and placebo (61 patients, 59 +/- 10 years) groups were similar (p > 0.05 for all). Post-procedural abnormal cTnI levels in the adenosine group were significantly lower than the placebo group (32 % vs. 55 %, p: 0.011). cTnI > 5 x ULN (21 % vs. 31 %, p: 0.217) and abnormal CK-MB levels (11 % vs. 19 %, p: 0.263) were similar in both groups. Post-procedural TFCs in the adenosine group were significantly lower than the placebo group (24 +/- 4 vs. 27 +/- 5, p: 0.004). In-hospital events including death and urgent TVR were not observed in either group. Conclusion Intracoronary administration of single-dose adenosine in patients with unstable angina undergoing PCI is associated with decreased periprocedural myonecrosis and improved coronary blood flow. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Myonecrosis | en_US |
dc.subject | Adenosine | en_US |
dc.subject | Percutaneous Coronary Intervention | en_US |
dc.subject | Unstable Angina | en_US |
dc.title | Impact of intracoronary adenosine on myonecrosis in patients with unstable angina pectoris undergoing percutaneous coronary intervention | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Cardiovascular Drugs and Therapy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-1919-3183 | en_US |
dc.authorid | 0000-0001-9975-5507 | en_US |
dc.authorid | 0000-0002-4607-5724 | en_US |
dc.authorid | 0000-0003-0230-6575 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 519 | en_US |
dc.identifier.endpage | 526 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s10557-015-6631-4 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |