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dc.contributor.authorGök, Özlem
dc.contributor.authorErmiş Karaali, Zeynep
dc.contributor.authorAcar, Leyla
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorErgen, Arzu
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:58Z
dc.date.issued2015en_US
dc.identifier.citationGök, Ö., Ermiş Karaali, Z., Acar, L., Kılıç, Ü. ve Ergen, A. (2015). ABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish population. Canadian Journal of Diabetes, 39(5), 405-410. https://dx.doi.org/10.1016/j.jcjd.2015.04.004en_US
dc.identifier.issn1499-2671
dc.identifier.urihttps://dx.doi.org/10.1016/j.jcjd.2015.04.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2116
dc.descriptionWOS: 000367036000011en_US
dc.descriptionPubMed ID: 26088706en_US
dc.description.abstractObjective: The aim of the present study was to investigate the relationship between ABCG5 and ABCG8 gene polymorphisms and plasma lipid concentrations in Turkish patients with type 2 diabetes mellitus. Methods: Included in this study were 80 patients with type 2 diabetes and 73 healthy controls. Two selected single nucleotide polymorphisms in ABC transporter genes, ABCG5 (rs6720173) and ABCG8 (rs4148211), were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism technique. Results: The rate of having the ABCG8 AA genotype (p = 0.001) was significantly higher in the patients than in the control subjects. Correspondingly, the rates of having the AG genotype (p = 0.001) and the G allele (p = 0.001) were significantly lower in the patients than in controls. Upon comparing the groups regarding ABCG5, the frequencies of occurrence of the GG genotype (p = 0.031) and G allele (p = 0.003) were considerably higher in patients than in control subjects. In the patients, the rates of having the CC genotype (p = 0.003) and the C allele (p = 0.031) were also significantly lower than those in control subjects. There was no significant difference between G5 and G8 polymorphism and lipid levels in the study groups. The ABCG8 AA genotype carriers had higher triglyceride (p = 0.045) and very low-density-cholesterol (p = 0.045) levels than the ABCG8 GG genotype carriers in all study populations. Conclusions: These results indicate that the AA genotype for ABCG8 and the GG genotype and G allele for ABCG5 are risk factors for diabetes. This study reveals the first data concerning the ABCG5 and ABCG8 gene polymorphisms in Turkish patients with diabetes.en_US
dc.description.sponsorshipResearch Fund of Istanbul University [6403]en_US
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University (Project #6403).en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectABCG5en_US
dc.subjectABCG8en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectLipid Metabolismen_US
dc.subjectPolymorphismen_US
dc.titleABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish populationen_US
dc.typearticleen_US
dc.relation.ispartofCanadian Journal of Diabetesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-6895-8560en_US
dc.identifier.volume39en_US
dc.identifier.issue5en_US
dc.identifier.startpage405en_US
dc.identifier.endpage410en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jcjd.2015.04.004en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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