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dc.contributor.authorDikkaya, Funda
dc.contributor.authorSarıcı, Ahmet Murat
dc.contributor.authorErbek, Firuze
dc.contributor.authorCelkan, Tiraje
dc.contributor.authorMangan, Mehmet Serhat
dc.contributor.authorAydın, Övgü
dc.contributor.authorDemirkesen, Cüyan
dc.contributor.authorPazarlı, Halit
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:55Z
dc.date.issued2018en_US
dc.identifier.citationDikkaya, F., Sarıcı, A., Erbek, F., Celkan, T., Mangan, M., Aydın, Ö. ... Pazarlı, H. (2018). Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy. International Ophthalmology, 38(1), 151-156. https://dx.doi.org/10.1007/s10792-016-0436-8en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.urihttps://dx.doi.org/10.1007/s10792-016-0436-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2103
dc.descriptionWOS: 000428760800023en_US
dc.descriptionPubMed ID: 28058667en_US
dc.description.abstractPurpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucleated for retinoblastoma and to analyze the association between growth pattern, rosetta formation, tumor thickness, presence of necrosis, calcification, neovascularization, rate of mitosis, and high-risk histopathologic factors. Methods Pathology reports of 59 eyes who had received enucleation for retinoblastoma were reviewed retrospectively. The histopathologic data included presence of choroidal invasion, optic nerve invasion, scleral extension, tumor thickness, presence of necrosis, calcification, neovascularization, rosetta formation and lymphocyte infiltration, rate of mitosis, and growth pattern. Results This study included 59 eyes from 30 (50.8%) male and 29 (49.2%) female patients. The mean age was 22.87 +/- 18.99 months. There were 30 (50.8%) eyes with choroidal invasion, 30 (50.8%) eyes with optic nerve invasion, and 5 (8.5%) eyes with scleral invasion. Endophytic growth pattern was seen in 27 (45.8%) eyes, exophytic growth pattern was seen in 2 (3.4%) eyes, and combined growth pattern was seen in 30 (50.8%) eyes. Exophytic growth pattern was found statistically related to choroidal invasion (p = 0.00). Although tumor with greater thickness tended to have more choroidal invasion (p = 0.02), there was no relation between tumor thickness and optic nerve invasion (p = 0.09). Conclusions Incidences of choroidal and optic nerve invasion showed similarity with other developing countries. Because of higher incidence of high-risk factors, intra-arterial chemotherapy with its targeted effect should be preferred carefully.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectRetinoblastomaen_US
dc.subjectHigh-Risk Histopathologic Factorsen_US
dc.subjectChoroidal Invasionen_US
dc.subjectOptic Nerve Invasionen_US
dc.titleEvaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapyen_US
dc.typearticleen_US
dc.relation.journalInternational Ophthalmologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0003-2312-2521en_US
dc.identifier.volume38en_US
dc.identifier.issue1en_US
dc.identifier.startpage151en_US
dc.identifier.endpage156en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10792-016-0436-8en_US


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