Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos

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info:eu-repo/semantics/embargoedAccessTarih
2018Yazar
Ateş, Perihan SedaÜnal, İsmail
Üstündağ, Ünsal Veli
Alturfan, Ahmet Ata
Yiğitbaşı, Türkan
Emekli Alturfan, Ebru
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Ateş, P., Ünal, İ., Üstündağ, Ü. V., Alturfan, A. A., Yiğitbaşı, T. ve Emekli Alturfan, E. (2018). Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos. Journal of Biochemical and Molecular Toxicology, 32(3). https://dx.doi.org/10.1002/jbt.22036Özet
Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure under sublethal doses are still unknown and the number of related studies is limited. Our aim was to evaluate the effects of MP on the development of zebrafish embryos focusing on development, locomotor activity, oxidant-antioxidant status, apoptosis, and ccnd1 and myca expressions. The expressions of ccnd1 and myca were determined by RT-PCR. Lipid peroxidation (LPO), nitric oxide (NO), and glutathione-S-transferase (GST) activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Locomotor activity was measured using touch-evoked movement test. MP exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group. Our findings will lead to further understanding of the mechanism of MP toxicity, and merit further research.
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Journal of Biochemical and Molecular ToxicologyCilt
32Sayı
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