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dc.contributor.authorYiğitbaşı, Türkan
dc.contributor.authorÇalıbaşı-Kocal, Gizem
dc.contributor.authorBüyükuslu, Nihal
dc.contributor.authorAtahan, Murat Kemal
dc.contributor.authorKüpeli, Hakan
dc.contributor.authorYiğit, Seyran
dc.contributor.authorTarcan, Ercüment
dc.contributor.authorBaskın, Yasemin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:49Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:49Z
dc.date.issued2018en_US
dc.identifier.citationYiğitbaşı, T., Çalıbaşı-Kocal, G., Büyükuslu, N., Atahan, M., Küpeli, H., Yiğit, S. ... Baskın, Y. (2018). An efficient biomarker panel for diagnosis of breast cancer using surface-enhanced laser desorption ionization time-of-flight mass spectrometry. Biomedical Reports, 8(3), 269-274. https://dx.doi.org/10.3892/br.2018.1042en_US
dc.identifier.issn2049-9434
dc.identifier.issn2049-9442
dc.identifier.urihttps://dx.doi.org/10.3892/br.2018.1042
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2082
dc.descriptionWOS: 000430743600009en_US
dc.descriptionPubMed ID: 29456844en_US
dc.description.abstractBreast cancer (BC) is the most frequently diagnosed cancer that affects women worldwide. Early detection of BC is important to improve survival rates and decrease mortality. The aim of the present study was to investigate serum biomarkers using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to distinguish patients with BC from the healthy population and patients with benign breast diseases (BBDs). A total of 62 patients with invasive ductal carcinoma, as confirmed by histopathology, and 47 non-cancerous individuals (NCIs) [16 healthy controls (HCs) and 31 patients with BBD] were enrolled in the present study. Serum protein profiles were determined by SELDI-TOF-MS using an immobilized metal affinity capture array. Serum from patients with BC were compared with that from the HC group using univariate and multivariate statistical analyses. A total of 118 clusters were generated from the individual serum. Univariate analysis revealed that 5 peaks were significantly downregulated (m/z 1,452, 2,670, 3,972, 5,354 and 5,523; P<0.001) and 4 were upregulated (m/z 6,850, 7,926, 8,115 and 8,143; P<0.001) in patients with BC compared with the HC group. A comparison of patients with BC and patients with BBD revealed an additional 9 protein peaks. Among these, 3 peaks (m/z 3,972, 5,336 and 11,185) were significantly downregulated and 6 peaks (m/z 4,062, 4,071, 4,609, 6,850, 8,115 and 8,133) were significantly upregulated. A total of 3 peaks [mass-to-change ratio (m/z) 3,972, 6,850 and 8,115 (BC2)] were common in both sets. The results of the present study suggest that a 4 protein peak set [m/z 3,972, 6,850 and 8,115 (BC2) and 8,949 (BC3)] could be used to distinguish patients with BC from NCI.en_US
dc.language.isoengen_US
dc.publisherSpandidos Publications Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectEarly Diagnosisen_US
dc.subjectBiomarkeren_US
dc.subjectProteomicsen_US
dc.subjectSurface-Enhanced Laser Desorption Ionization Time-Of-Flight Mass Spectrometryen_US
dc.titleAn efficient biomarker panel for diagnosis of breast cancer using surface-enhanced laser desorption ionization time-of-flight mass spectrometryen_US
dc.typearticleen_US
dc.relation.ispartofBiomedical Reportsen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.authorid0000-0002-0675-1839en_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.startpage269en_US
dc.identifier.endpage274en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3892/br.2018.1042en_US
dc.identifier.scopusqualityQ1en_US


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