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dc.contributor.authorBabiloni, Claudio
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorCatania, Valentina
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorBonanni, Laura
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorGarn, Heinrich
dc.contributor.authorFraioli, Lucia
dc.contributor.authorPievanim, Michela
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBaşar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek-Savas, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorDe Pandis, Maria Francesca
dc.contributor.authorVacca, Laura
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorStocchi, Fabrizio
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:42Z
dc.date.issued2018en_US
dc.identifier.citationBabiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Stocchi, F. (2018). Functional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseases. Clinical Neurophysiology, 129(4), 766-782. https://dx.doi.org/10.1016/j.clinph.2018.01.009en_US
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.urihttps://dx.doi.org/10.1016/j.clinph.2018.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2053
dc.descriptionWOS: 000427485900009en_US
dc.descriptionPubMed ID: 29448151en_US
dc.description.abstractObjective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer's (ADMCI) and Parkinson's (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N = 75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70-0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment.en_US
dc.description.sponsorshipH Marie S. Curie ITN-ETN projecten_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. Dr. Erol Basar passed away due to health problems on October 28th (November 18th 1938-October 28th 2017) in Istanbul, during the editorial processing of this manuscript. Until the end of his life, he had been working to the development of EEG science and its application in Clinical Neurophysiology. He leaves to all us an invaluable scientific legacy in the Science of Brain Rhythms and Human Cognition. He also leaves a permanent reminder of scientific passion, academic soul, and social responsibility to all fortunate people who met and knew him during his intense life. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-ITNetn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional Brain Connectivityen_US
dc.subjectResting State EEG Rhythmsen_US
dc.subjectMild Cognitive Impairment Due Toen_US
dc.subjectAlzheimer's Disease (ADMCI)en_US
dc.subjectMild Cognitive Impairment Due Toen_US
dc.subjectParkinson's Disease (PDMCI)en_US
dc.titleFunctional cortical source connectivity of resting state electroencephalographic alpha rhythms shows similar abnormalities in patients with mild cognitive impairment due to Alzheimer's and Parkinson's diseasesen_US
dc.typearticleen_US
dc.relation.ispartofClinical Neurophysiologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume129en_US
dc.identifier.issue4en_US
dc.identifier.startpage766en_US
dc.identifier.endpage782en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.clinph.2018.01.009en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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