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dc.contributor.authorAltuntaş, Ebru
dc.contributor.authorYener, Gülgün
dc.contributor.authorDoğan, Remzi
dc.contributor.authorAksoy, Fadlullah
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorKarataş, Ersin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:39Z
dc.date.issued2018en_US
dc.identifier.citationAltuntaş, E., Yener, G., Doğan, R., Aksoy, F., Aydın, M. ve Karataş, E. (2018). Effects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis model. American Journal of Rhinology & Allergy, 32(3), 132-138. https://dx.doi.org/10.1177/1945892418764951en_US
dc.identifier.issn1945-8924
dc.identifier.issn1945-8932
dc.identifier.urihttps://dx.doi.org/10.1177/1945892418764951
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2043
dc.descriptionWOS: 000432900700002en_US
dc.descriptionPubMed ID: 29644886en_US
dc.description.abstractBackground: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective: The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis. Methods: An experimental allergic rhinitis model was developed in female Wistar albino rats by intraperitoneal injection of ovalbumin every 2 days for 14 days followed by its repeated intranasal instillation for 7 consecutive days. Intranasal instillation of ovalbumin was continued every other day for 14 days. Mometasone furoate in situ gel (5 mu g/10 mu l), mometasone furoate suspension (5 mu g/10 mu l), and physiological saline (10 ml) were administered into the bilateral nasal cavities from day 22 to day 35. Antiallergic effects were evaluated through histopathological evaluation, analysis of ovalbumin-specific serum immunoglobulin E, and a symptom score. Results: Mometasone furoate in situ gel significantly decreased the nasal symptoms and ovalbumin-specific serum immunoglobulin E level as compared with mometasone furoate suspension and physiological saline. Additionally, inflammatory histological symptoms such as mucosal edema, vascular dilatation, eosinophil infiltration, and loss of cilia within the nasal mucosa of allergic rhinitis model rats were remarkably improved with the treatment of mometasone furoate in situ gel. Conclusion: These results suggest that mometasone furoate in situ gel has a better therapeutic potential for the treatment of allergic rhinitis compared to mometasone furoate suspension.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University [41584]; TUBITAK (The Scientific & Technological Research Council of Turkey) [114S820, 1002]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Scientific Research Project Coordination Unit of Istanbul University (Project Number: 41584) and Rapid Support Program (1002) of TUBITAK (The Scientific & Technological Research Council of Turkey (Project Number: 114S820).en_US
dc.language.isoengen_US
dc.publisherSage Publications Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThermosensitiveen_US
dc.subjectIn Situ Gelen_US
dc.subjectMucoadhesiveen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectMometasone Furoateen_US
dc.subjectIntranasal Corticosteroidsen_US
dc.subjectSuspensionen_US
dc.subjectRat modelen_US
dc.subjectOvalbuminen_US
dc.subjectImmunoglobulinen_US
dc.subjectHistopathological Evaluationen_US
dc.titleEffects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis modelen_US
dc.typearticleen_US
dc.relation.journalAmerican Journal of Rhinology & Allergyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-6393-1465en_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.startpage132en_US
dc.identifier.endpage138en_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/114S820 1002en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1177/1945892418764951en_US


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