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dc.contributor.authorBabiloni, Claudio
dc.contributor.authordel Percio, Claudio
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorAarsland, Dag
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorGarn, Heinrich
dc.contributor.authorFraioli, Lucia
dc.contributor.authorPievani, Michela
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorde Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorBazar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorTaylor, John Paul
dc.contributor.authorVacca, Laura
dc.contributor.authorde Pandis, Maria Francesca
dc.contributor.authorBonanni, Laura
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:37Z
dc.date.issued2018en_US
dc.identifier.citationBabiloni, C., del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A. ... Bonanni, L. (2018). Abnormalities of resting-state functional cortical connectivity in patients with dementia due to alzheimer's and lewy body diseases: An EEG study. Neurobiology of Aging, 65, 18-40. https://dx.doi.org/10.1016/j.neurobiolaging.2017.12.023en_US
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2017.12.023
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2033
dc.descriptionWOS: 000428233700003en_US
dc.descriptionPubMed ID: 29407464en_US
dc.description.abstractPrevious evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values>0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels.en_US
dc.description.sponsorshipH2020 Marie S. Curie ITN-ETN projecten_US
dc.description.sponsorshipThe present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bddiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFunctional Brain Connectivityen_US
dc.subjectResting State EEG Rhythmsen_US
dc.subjectNeurodegenerative Diseasesen_US
dc.subjectDementiaen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectDementia With Lewy Bodiesen_US
dc.titleAbnormalities of resting-state functional cortical connectivity in patients with dementia due to alzheimer's and lewy body diseases: An EEG studyen_US
dc.typearticleen_US
dc.relation.journalNeurobiology of Agingen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume65en_US
dc.identifier.startpage18en_US
dc.identifier.endpage40en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.neurobiolaging.2017.12.023en_US


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