Show simple item record

dc.contributor.authorDoğan, Remzi
dc.contributor.authorEren, Sabri Baki
dc.contributor.authorGedik, Özge
dc.contributor.authorYenigün, Alper
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorEser, Büşranur
dc.contributor.authorÖzturan, Orhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:35Z
dc.date.issued2018en_US
dc.identifier.citationDoğan, R., Eren, S. B., Gedik, Ö., Yenigün, A., Aydın, M. Ş., Eser, B. ... Özturan, O. (2018). Different concentrations of mesna application have an effect on the internal ear? International Journal of Pediatric Otorhinolaryngology, 109, 31-35. https://dx.doi.org/10.1016/j.ijporl.2018.03.020en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijporl.2018.03.020
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2022
dc.descriptionWOS: 000432766000007en_US
dc.descriptionPubMed ID: 29728180en_US
dc.description.abstractObjective: The use of Mesna as a chemical dissector in higher concentrations may reduce the length of time of operation by providing more effective dissection as well as being used in otologic pathologies such as tympanosclerosis. In this study, it was aimed to assess the effect of Mesna on the internal ear, which was applied intra-tympanically in higher concentrations than the conventional use. Methods: Twenty-four female rats were included in our study. The rats were randomly divided into three groups (Group 1: Mesna 50%, Group 2: Mesna 100%, Group 3: Saline). At the beginning of the study, DPOAE and ABR measurements were carried out on every rat on days 7 and 14. At the end of the study, cochleas of the rats were excised and histopathological assessments were carried out. Results: Basal values and DPOAE and ABR values on day 7 and 14 of Group 1, Group 2, and Group 3 were similar to each other. No significant difference was detected among the three groups in the histopathological assessment carried out at the end of the study. Conclusion: It was revealed by audiological and histopathological parameters that the use of Mesna at 50% and 100% concentrations did not create toxicity effects on the internal ear. Mesna would be more effective by being used in higher concentrations in audiological surgeries, that its duration of operation world reduce and could being used in different indications including tympanosclerosis.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectABRen_US
dc.subjectDPOAEen_US
dc.subjectHistopathologyen_US
dc.subjectMesnaen_US
dc.subjectOtotoxicityen_US
dc.titleDifferent concentrations of mesna application have an effect on the internal ear?en_US
dc.typearticleen_US
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Odyoloji Bölümüen_US
dc.authorid0000-0002-6393-1465en_US
dc.identifier.volume109en_US
dc.identifier.startpage31en_US
dc.identifier.endpage35en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ijporl.2018.03.020en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record