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dc.contributor.authorBatırel, Hasan Fevzi
dc.contributor.authorMetintaş, Muzaffer
dc.contributor.authorÇağlar, Hale Başak
dc.contributor.authorAk, Güntülü
dc.contributor.authorYumuk, Perran Fulden
dc.contributor.authorAhıskalı, Rengin
dc.contributor.authorBozkurtlar, Emine
dc.contributor.authorBekiroğlu, Nural
dc.contributor.authorLaçin, Tunç
dc.contributor.authorYıldızeli, Bedrettin
dc.contributor.authorYüksel, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:34Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:34Z
dc.date.issued2018en_US
dc.identifier.citationBatırel, H., Metintaş, M., Çağlar, H. B., Ak, G., Yumuk, P., Ahıskalı, R. ... Yüksel, M. (2018). Macroscopic complete resection is not associated with improved survival in patients with malignant pleural mesothelioma. Journal of Thoracic and Cardiovascular Surgery, 155(6). 2724-2732. https://dx.doi.org/10.1016/j.jtcvs.2017.12.131en_US
dc.identifier.issn0022-5223
dc.identifier.issn1097-685X
dc.identifier.urihttps://dx.doi.org/10.1016/j.jtcvs.2017.12.131
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2020
dc.description97th Annual Meeting of the American-Association-for-Thoracic-Surgery -- APR 29-MAY 03, 2017 -- Boston, MAen_US
dc.descriptionWOS: 000432369400123en_US
dc.descriptionPubMed ID: 29510939en_US
dc.description.abstractObjective: Macroscopic complete resection (MCR) is the recommended surgical strategy in malignant pleural mesothelioma. Our objective was to analyze whether MCR influences survival in malignant pleural mesothelioma. Methods: Between 2002 and 2016, 154 patients underwent pleurectomy decortication (n = 90), extrapleural pneumonectomy (n = 42), or exploratory/diagnostic procedures (n = 22) in a single institution. Patient data were recorded in a prospective database. Patients who underwent surgical resection (n = 132) were analyzed according to MCR as a whole group and after propensity score matching based on gender, age, histology, clinical T and N status, adjuvant chemotherapy, and trimodality treatment. Kaplan-Meier survival and univariate and multivariate analyses were performed. Results: Median age was 56 years (range, 26 to 80 years) and 62 were women. One hundred ten had epithelioid histology. MCR was achieved in 75 patients (49%). In-hospital mortality was seen in 7 patients (4.5%). Preoperative chemotherapy was applied in 32 patients. One hundred thirty-three patients underwent adjuvant treatment (45 had chemoradiation). Mean follow-up was 21 +/- 19 months. Overall median survival, 2-year, and 5-year survivals were 18.1 months, 36%, and 16%, respectively. There was no difference in median survival between patients who underwent MCR (21.4 months) and who did not (16.3 months) (P = .6). Following propensity score matching (23 patients in each group), median survivals were similar (13.3 vs 14.2 months; P = .63). Conclusions: MCR was not associated with improved survival in malignant pleural mesothelioma. We need to clearly define MCR and identify subgroups of patients who would benefit from this principle because minimal versus extensive and location of gross residual disease may have different influences on survival.en_US
dc.description.sponsorshipAmerican Association for Thoracic Surgeryen_US
dc.language.isoengen_US
dc.publisherMosby-Elsevieren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectMacroscopic Complete Resectionen_US
dc.titleMacroscopic complete resection is not associated with improved survival in patients with malignant pleural mesotheliomaen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Thoracic and Cardiovascular Surgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalıen_US
dc.identifier.volume155en_US
dc.identifier.issue6en_US
dc.identifier.startpage2724en_US
dc.identifier.endpage2732en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jtcvs.2017.12.131en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.scopusqualityQ1en_US


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